FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1931194953> ?p ?o ?g. }

• W1931194953 endingPage "2870" @default.
• W1931194953 startingPage "2866" @default.
• W1931194953 abstract "Streptococcus pneumoniae is a major respiratory pathogen of infants, children, and the elderly. Polysaccharide vaccines have been useful in adult populations but do not elicit protective immunity in infants and young children. To enhance their immunogenicity, vaccines of pneumococcal polysaccharides conjugated to proteins are being developed. In this study antibody levels and opsonic activities were compared in sera of infants and adults injected with pneumococcal polysaccharide type 6B (Pn6B) conjugated to tetanus toxoid (TT) (Pn6B-TT). Healthy infants were injected with Pn6B-TT; group A was injected at 3, 4, and 6 months of age, and group B was injected at 7 and 9 months of age. A booster injection was given at 18 months. Adults were injected once. Antibodies were measured by enzyme-linked immunosorbent assay and radioimmunoassay, and their functional activities were measured by opsonophagocytosis of radiolabelled pneumococci. In adults, increases in immunoglobulin M (IgM), IgG, IgA, IgG1, and IgG2 to Pn6B were observed. Infants reached adult levels of IgG1 anti-Pn6B after the primary injections. After the booster injection the infant groups had total IgG- and IgM-Pn6B antibody levels similar to those of adults. After the booster injection, IgG1 was the dominant infant anti-Pn6B isotype and at a level higher than in vaccinated adults, but IgA and IgG2 antibodies remained at very low levels. Opsonic activity increased significantly after Pn6B-TT injections; the highest infant sera showed opsonic activity comparable to that of vaccinated adults. Overall, opsonic activity correlated best with total and IgG anti-Pn6B antibodies (r = 0.741, r = 0.653, respectively; n = 35) and was highest in sera with high levels of all Pn6B antibody isotypes. The results indicate the protective potential of a pneumococcal 6B polysaccharide protein conjugate vaccine for young infants." @default.
• W1931194953 created "2016-06-24" @default.
• W1931194953 creator A5000480270 @default.
• W1931194953 creator A5001994531 @default.
• W1931194953 creator A5003556600 @default.
• W1931194953 creator A5027784931 @default.
• W1931194953 creator A5027823139 @default.
• W1931194953 creator A5049232805 @default.
• W1931194953 creator A5068876026 @default.
• W1931194953 creator A5073049526 @default.
• W1931194953 creator A5073568157 @default.
• W1931194953 creator A5084181720 @default.
• W1931194953 creator A5086891073 @default.
• W1931194953 date "1998-06-01" @default.
• W1931194953 modified "2023-09-26" @default.
• W1931194953 title "Isotypes and Opsonophagocytosis of Pneumococcus Type 6B Antibodies Elicited in Infants and Adults by an Experimental Pneumococcus Type 6B-Tetanus Toxoid Vaccine" @default.
• W1931194953 cites W1817930542 @default.
• W1931194953 cites W1874318404 @default.
• W1931194953 cites W1956712871 @default.
• W1931194953 cites W1966004707 @default.
• W1931194953 cites W1971408348 @default.
• W1931194953 cites W1975608671 @default.
• W1931194953 cites W1978102493 @default.
• W1931194953 cites W1979720265 @default.
• W1931194953 cites W1979806098 @default.
• W1931194953 cites W1980457977 @default.
• W1931194953 cites W1981007703 @default.
• W1931194953 cites W1988422289 @default.
• W1931194953 cites W1993123817 @default.
• W1931194953 cites W1996109838 @default.
• W1931194953 cites W2006744267 @default.
• W1931194953 cites W2008174611 @default.
• W1931194953 cites W2020152958 @default.
• W1931194953 cites W2035070067 @default.
• W1931194953 cites W204218960 @default.
• W1931194953 cites W2042526666 @default.
• W1931194953 cites W2045221557 @default.
• W1931194953 cites W2066543008 @default.
• W1931194953 cites W2069992170 @default.
• W1931194953 cites W2114489085 @default.
• W1931194953 cites W2121445679 @default.
• W1931194953 cites W2152013539 @default.
• W1931194953 cites W2157765407 @default.
• W1931194953 cites W2223662840 @default.
• W1931194953 cites W2238786570 @default.
• W1931194953 cites W2313083727 @default.
• W1931194953 cites W2320901227 @default.
• W1931194953 cites W2334571466 @default.
• W1931194953 cites W2342228817 @default.
• W1931194953 cites W2399895279 @default.
• W1931194953 cites W3025761000 @default.
• W1931194953 cites W4243694995 @default.
• W1931194953 cites W4246408163 @default.
• W1931194953 cites W98228656 @default.
• W1931194953 doi "https://doi.org/10.1128/iai.66.6.2866-2870.1998" @default.
• W1931194953 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/108283" @default.
• W1931194953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9596761" @default.
• W1931194953 hasPublicationYear "1998" @default.
• W1931194953 type Work @default.
• W1931194953 sameAs 1931194953 @default.
• W1931194953 citedByCount "67" @default.
• W1931194953 countsByYear W19311949532012 @default.
• W1931194953 countsByYear W19311949532013 @default.
• W1931194953 countsByYear W19311949532014 @default.
• W1931194953 countsByYear W19311949532015 @default.
• W1931194953 countsByYear W19311949532016 @default.
• W1931194953 countsByYear W19311949532017 @default.
• W1931194953 countsByYear W19311949532018 @default.
• W1931194953 countsByYear W19311949532023 @default.
• W1931194953 crossrefType "journal-article" @default.
• W1931194953 hasAuthorship W1931194953A5000480270 @default.
• W1931194953 hasAuthorship W1931194953A5001994531 @default.
• W1931194953 hasAuthorship W1931194953A5003556600 @default.
• W1931194953 hasAuthorship W1931194953A5027784931 @default.
• W1931194953 hasAuthorship W1931194953A5027823139 @default.
• W1931194953 hasAuthorship W1931194953A5049232805 @default.
• W1931194953 hasAuthorship W1931194953A5068876026 @default.
• W1931194953 hasAuthorship W1931194953A5073049526 @default.
• W1931194953 hasAuthorship W1931194953A5073568157 @default.
• W1931194953 hasAuthorship W1931194953A5084181720 @default.
• W1931194953 hasAuthorship W1931194953A5086891073 @default.
• W1931194953 hasBestOaLocation W19311949531 @default.
• W1931194953 hasConcept C12590561 @default.
• W1931194953 hasConcept C159654299 @default.
• W1931194953 hasConcept C203014093 @default.
• W1931194953 hasConcept C22070199 @default.
• W1931194953 hasConcept C2776152631 @default.
• W1931194953 hasConcept C2776548049 @default.
• W1931194953 hasConcept C2777351567 @default.
• W1931194953 hasConcept C2779102806 @default.
• W1931194953 hasConcept C2779301066 @default.
• W1931194953 hasConcept C2779341262 @default.
• W1931194953 hasConcept C2779841045 @default.
• W1931194953 hasConcept C2780801004 @default.
• W1931194953 hasConcept C2780868878 @default.
• W1931194953 hasConcept C2780898057 @default.
• W1931194953 hasConcept C2781253189 @default.
• W1931194953 hasConcept C501593827 @default.

• next