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- W1931225401 abstract "Three-month-old C3H female mice were given injections of 5-mg pieces of mammary adenocarcinoma and were then fed diets that either were fat free or contained saturated fat (15% hydrogenated cottonseed oil) or linoleate (1–15% corn oil). After 6 weeks, the tumors in mice fed the linoleate diet weighed 3–4 times more than those in mice fed the fat-free or saturated-fat diets. Despite a linoleate-free diet, tumors contained appreciable amounts of linoleate and arachidonate (≈2 and 9% of the total fatty acids, respectively). When the level of dietary corn oil was increased from 1 to 15%, the linoleate content of the tumors increased from 4 to 18% of the total fatty acids. However, in these instances, the tumor arachidonate levels increased to maximum values even when the 1% corn oil diet was used. These observations shOWed that mammary tumor growth was depressed by a fat-free or saturated-fat diet and enhanced by dietary linoleate. Furthermore, they suggested that the growth rate was related to the arachidonate content rather than the linoleate content of the tumors." @default.
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- W1931225401 title "Enhanced Growth Rate of Transplanted Mammary Adenocarcinoma Induced in C3H Mice by Dietary Linoleate2" @default.
- W1931225401 doi "https://doi.org/10.1093/jnci/56.2.431" @default.
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