Matches in SemOpenAlex for { <https://semopenalex.org/work/W1931285493> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1931285493 abstract "Advances in culture-independent methods allow a more extensive characterisation of the fungal community of the CF lung. This study uses a high-throughput sequencing technique to profile the fungal microbiota of the stable CF airway, and correlates this with culture-based methods and clinical phenotype.Clinically stable adult CF patients were prospectively recruited from our Adult CF Centre. Culture-based methods were employed at time of sampling. Fungal DNA was extracted from all samples. High-throughput bar-coded sequencing targeting the internal transcribed spacer (ITS) region was used to profile the fungal microbiota of all sputum samples. Clinical charcteristics were recorded by retrospective review of medical notes.55 clinically stable adult CF patients were recruited. Culture-based methods detected fungus in 15 of the 55 samples. High-throughput bar-coded sequencing identified rich fungal communities in greater than 90% of the samples, with over 82% of the species not detected by culture. A preliminary comparison of patient status with diversity and species richness of fungal microbiota identified that lower fungal diversity associates with decreased lung function.We describe the use of high-throughput sequencing to characterize the fungal microbiota in the largest population of adult patients with CF to date. DNA analysis reveals increased species diversity and richness compared with standard culture-based methods. Preliminary analysis suggests that fungal diversity may contribute to, or be associated with, variability in phenotype seen in CF patients." @default.
- W1931285493 created "2016-06-24" @default.
- W1931285493 creator A5002975186 @default.
- W1931285493 creator A5012496988 @default.
- W1931285493 creator A5031422226 @default.
- W1931285493 creator A5054262742 @default.
- W1931285493 creator A5056753243 @default.
- W1931285493 creator A5061335694 @default.
- W1931285493 creator A5081933257 @default.
- W1931285493 creator A5087650586 @default.
- W1931285493 date "2013-09-01" @default.
- W1931285493 modified "2023-09-27" @default.
- W1931285493 title "LSC 2013 abstract - The role of second-generation sequencing to characterize the fungal microbiota in the adult cystic fibrosis airway, and its correlation with standard culture-based methods and clinical phenotype" @default.
- W1931285493 hasPublicationYear "2013" @default.
- W1931285493 type Work @default.
- W1931285493 sameAs 1931285493 @default.
- W1931285493 citedByCount "2" @default.
- W1931285493 countsByYear W19312854932017 @default.
- W1931285493 countsByYear W19312854932018 @default.
- W1931285493 crossrefType "journal-article" @default.
- W1931285493 hasAuthorship W1931285493A5002975186 @default.
- W1931285493 hasAuthorship W1931285493A5012496988 @default.
- W1931285493 hasAuthorship W1931285493A5031422226 @default.
- W1931285493 hasAuthorship W1931285493A5054262742 @default.
- W1931285493 hasAuthorship W1931285493A5056753243 @default.
- W1931285493 hasAuthorship W1931285493A5061335694 @default.
- W1931285493 hasAuthorship W1931285493A5081933257 @default.
- W1931285493 hasAuthorship W1931285493A5087650586 @default.
- W1931285493 hasConcept C104317684 @default.
- W1931285493 hasConcept C127716648 @default.
- W1931285493 hasConcept C142724271 @default.
- W1931285493 hasConcept C143121216 @default.
- W1931285493 hasConcept C15151743 @default.
- W1931285493 hasConcept C18903297 @default.
- W1931285493 hasConcept C2776301714 @default.
- W1931285493 hasConcept C2776938444 @default.
- W1931285493 hasConcept C2778600591 @default.
- W1931285493 hasConcept C2779678110 @default.
- W1931285493 hasConcept C2781069245 @default.
- W1931285493 hasConcept C2908647359 @default.
- W1931285493 hasConcept C51679486 @default.
- W1931285493 hasConcept C53565203 @default.
- W1931285493 hasConcept C54355233 @default.
- W1931285493 hasConcept C552990157 @default.
- W1931285493 hasConcept C59822182 @default.
- W1931285493 hasConcept C71924100 @default.
- W1931285493 hasConcept C86803240 @default.
- W1931285493 hasConcept C99454951 @default.
- W1931285493 hasConceptScore W1931285493C104317684 @default.
- W1931285493 hasConceptScore W1931285493C127716648 @default.
- W1931285493 hasConceptScore W1931285493C142724271 @default.
- W1931285493 hasConceptScore W1931285493C143121216 @default.
- W1931285493 hasConceptScore W1931285493C15151743 @default.
- W1931285493 hasConceptScore W1931285493C18903297 @default.
- W1931285493 hasConceptScore W1931285493C2776301714 @default.
- W1931285493 hasConceptScore W1931285493C2776938444 @default.
- W1931285493 hasConceptScore W1931285493C2778600591 @default.
- W1931285493 hasConceptScore W1931285493C2779678110 @default.
- W1931285493 hasConceptScore W1931285493C2781069245 @default.
- W1931285493 hasConceptScore W1931285493C2908647359 @default.
- W1931285493 hasConceptScore W1931285493C51679486 @default.
- W1931285493 hasConceptScore W1931285493C53565203 @default.
- W1931285493 hasConceptScore W1931285493C54355233 @default.
- W1931285493 hasConceptScore W1931285493C552990157 @default.
- W1931285493 hasConceptScore W1931285493C59822182 @default.
- W1931285493 hasConceptScore W1931285493C71924100 @default.
- W1931285493 hasConceptScore W1931285493C86803240 @default.
- W1931285493 hasConceptScore W1931285493C99454951 @default.
- W1931285493 hasLocation W19312854931 @default.
- W1931285493 hasOpenAccess W1931285493 @default.
- W1931285493 hasPrimaryLocation W19312854931 @default.
- W1931285493 hasRelatedWork W1803750729 @default.
- W1931285493 hasRelatedWork W2006586953 @default.
- W1931285493 hasRelatedWork W2008521575 @default.
- W1931285493 hasRelatedWork W2029374202 @default.
- W1931285493 hasRelatedWork W2096288151 @default.
- W1931285493 hasRelatedWork W2116180558 @default.
- W1931285493 hasRelatedWork W2134564677 @default.
- W1931285493 hasRelatedWork W2272670051 @default.
- W1931285493 hasRelatedWork W2731624152 @default.
- W1931285493 hasRelatedWork W2733925279 @default.
- W1931285493 hasRelatedWork W2739855013 @default.
- W1931285493 hasRelatedWork W2759413496 @default.
- W1931285493 hasRelatedWork W2801768664 @default.
- W1931285493 hasRelatedWork W2922424679 @default.
- W1931285493 hasRelatedWork W2922735817 @default.
- W1931285493 hasRelatedWork W2942088753 @default.
- W1931285493 hasRelatedWork W2945625818 @default.
- W1931285493 hasRelatedWork W2993891716 @default.
- W1931285493 hasRelatedWork W3040580712 @default.
- W1931285493 hasRelatedWork W3081142897 @default.
- W1931285493 hasVolume "42" @default.
- W1931285493 isParatext "false" @default.
- W1931285493 isRetracted "false" @default.
- W1931285493 magId "1931285493" @default.
- W1931285493 workType "article" @default.