Matches in SemOpenAlex for { <https://semopenalex.org/work/W1931329966> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1931329966 endingPage "523" @default.
- W1931329966 startingPage "518" @default.
- W1931329966 abstract "The genome of the Snyder-Theilen strain of feline sarcoma virus (ST-FeSV) is a 4.3-kilobase-pair (kbp) RNA molecule that contains a 1.5-kbp cellular insertion (fes gene) flanked by feline leukemia virus sequences at its 5' end (1.6 kbp) and 3' end (1.2 kbp) (Sherr et al., J. Virol. 34:200-212, 1980). DNA transfection techniques have been utilized to determine the regions of the ST-FeSV genome involved in malignant transformation. I have found that the 3.7-kbp 5'-end fragment of the ST-FeSV provirus (which corresponds to the 3.4-kbp 5'-end fragment of the viral genome) is sufficient to transform NIH/3T3 fibroblasts. Enzymes that cleave the ST-FeSV provirus DNA within the feline leukemia virus gag gene sequences or within the fes gene abolished the transforming activity. Preservation of the proviral large terminal repeats was also required for transformation. Transformed NIH/3T3 cells obtained by transfection of total or subgenomic ST-FeSV DNA expressed normal levels of the ST-FeSV gene product ST P85 and of its associated protein kinase activity. Furthermore, these cells contained high levels of phosphotyrosine residues, a biochemical marker associated with cellular transformation induced by certain retroviruses including ST-FeSV. These results, taken together, strongly support the concept that only those ST-FeSV proviral sequences necessary for ST P85 expression are involved in malignant transformation." @default.
- W1931329966 created "2016-06-24" @default.
- W1931329966 creator A5056668478 @default.
- W1931329966 date "1981-01-01" @default.
- W1931329966 modified "2023-09-26" @default.
- W1931329966 title "Cellular transformation by subgenomic feline sarcoma virus DNA" @default.
- W1931329966 cites W1485015721 @default.
- W1931329966 cites W1572577713 @default.
- W1931329966 cites W1580974473 @default.
- W1931329966 cites W1592665250 @default.
- W1931329966 cites W1814593256 @default.
- W1931329966 cites W1837010528 @default.
- W1931329966 cites W1958265700 @default.
- W1931329966 cites W1964265039 @default.
- W1931329966 cites W1965372133 @default.
- W1931329966 cites W1967700466 @default.
- W1931329966 cites W1983261245 @default.
- W1931329966 cites W1993152706 @default.
- W1931329966 cites W2002969503 @default.
- W1931329966 cites W2003591463 @default.
- W1931329966 cites W2005679493 @default.
- W1931329966 cites W2009421727 @default.
- W1931329966 cites W2011147958 @default.
- W1931329966 cites W2027203331 @default.
- W1931329966 cites W2047551991 @default.
- W1931329966 cites W2049214213 @default.
- W1931329966 cites W2052306061 @default.
- W1931329966 cites W2056770304 @default.
- W1931329966 cites W2057799558 @default.
- W1931329966 cites W2059944708 @default.
- W1931329966 cites W2063450941 @default.
- W1931329966 cites W2069117268 @default.
- W1931329966 cites W2079507934 @default.
- W1931329966 cites W2161503938 @default.
- W1931329966 cites W2254899440 @default.
- W1931329966 cites W4243780619 @default.
- W1931329966 cites W1985268245 @default.
- W1931329966 doi "https://doi.org/10.1128/jvi.37.1.518-523.1981" @default.
- W1931329966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/171032" @default.
- W1931329966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6261000" @default.
- W1931329966 hasPublicationYear "1981" @default.
- W1931329966 type Work @default.
- W1931329966 sameAs 1931329966 @default.
- W1931329966 citedByCount "26" @default.
- W1931329966 countsByYear W19313299662012 @default.
- W1931329966 countsByYear W19313299662014 @default.
- W1931329966 crossrefType "journal-article" @default.
- W1931329966 hasAuthorship W1931329966A5056668478 @default.
- W1931329966 hasBestOaLocation W19313299661 @default.
- W1931329966 hasConcept C102906071 @default.
- W1931329966 hasConcept C104317684 @default.
- W1931329966 hasConcept C141231307 @default.
- W1931329966 hasConcept C153911025 @default.
- W1931329966 hasConcept C159047783 @default.
- W1931329966 hasConcept C189819185 @default.
- W1931329966 hasConcept C199491388 @default.
- W1931329966 hasConcept C204241405 @default.
- W1931329966 hasConcept C2522874641 @default.
- W1931329966 hasConcept C54009773 @default.
- W1931329966 hasConcept C54355233 @default.
- W1931329966 hasConcept C552990157 @default.
- W1931329966 hasConcept C6881719 @default.
- W1931329966 hasConcept C86803240 @default.
- W1931329966 hasConceptScore W1931329966C102906071 @default.
- W1931329966 hasConceptScore W1931329966C104317684 @default.
- W1931329966 hasConceptScore W1931329966C141231307 @default.
- W1931329966 hasConceptScore W1931329966C153911025 @default.
- W1931329966 hasConceptScore W1931329966C159047783 @default.
- W1931329966 hasConceptScore W1931329966C189819185 @default.
- W1931329966 hasConceptScore W1931329966C199491388 @default.
- W1931329966 hasConceptScore W1931329966C204241405 @default.
- W1931329966 hasConceptScore W1931329966C2522874641 @default.
- W1931329966 hasConceptScore W1931329966C54009773 @default.
- W1931329966 hasConceptScore W1931329966C54355233 @default.
- W1931329966 hasConceptScore W1931329966C552990157 @default.
- W1931329966 hasConceptScore W1931329966C6881719 @default.
- W1931329966 hasConceptScore W1931329966C86803240 @default.
- W1931329966 hasIssue "1" @default.
- W1931329966 hasLocation W19313299661 @default.
- W1931329966 hasLocation W19313299662 @default.
- W1931329966 hasLocation W19313299663 @default.
- W1931329966 hasOpenAccess W1931329966 @default.
- W1931329966 hasPrimaryLocation W19313299661 @default.
- W1931329966 hasRelatedWork W100888133 @default.
- W1931329966 hasRelatedWork W1511159130 @default.
- W1931329966 hasRelatedWork W1931329966 @default.
- W1931329966 hasRelatedWork W1980205374 @default.
- W1931329966 hasRelatedWork W2012849123 @default.
- W1931329966 hasRelatedWork W2032980371 @default.
- W1931329966 hasRelatedWork W2079024424 @default.
- W1931329966 hasRelatedWork W2266664725 @default.
- W1931329966 hasRelatedWork W2296667177 @default.
- W1931329966 hasRelatedWork W2330413721 @default.
- W1931329966 hasVolume "37" @default.
- W1931329966 isParatext "false" @default.
- W1931329966 isRetracted "false" @default.
- W1931329966 magId "1931329966" @default.
- W1931329966 workType "article" @default.