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- W1931451724 abstract "In the inner ear, fast excitatory synaptic transmission is mediated by ionotropic glutamate receptors, including AMPA, kainate, and NMDA receptors. The recently identified δ1 and δ2 glutamate receptors share low homology with the other three types, and no clear response or ligand binding has been obtained from cells transfected with δ alone or in combination with other ionotropic receptors. Studies of mice lacking expression of δ2 show that this subunit plays a crucial role in plasticity of cerebellar glutamatergic synapses. In addition, these mice show a deficit in vestibular compensation. These findings and the nature of glutamatergic synapses between vestibulocochlear hair cells and primary afferent dendrites suggest that δ receptors may be functionally important in the inner ear and prompted us to investigate the expression of δ receptors in the cochlea and peripheral vestibular system. Reverse transcription and DNA amplification by PCR combined with immunocytochemistry and in situ hybridization were used. Our results show that the expression of δ1 in the organ of Corti is intense and restricted to the inner hair cells, whereas δ1 is expressed in all spiral ganglion neurons as well as in their satellite glial cells. In the vestibular end organ, δ1 was highly expressed in both hair cell types and also was expressed in the vestibular ganglion neurons. The prominent expression of δ1 in inner hair cells and in type I and type II vestibular hair cells suggests a functional role in hair cell neurotransmission." @default.
- W1931451724 created "2016-06-24" @default.
- W1931451724 creator A5022304025 @default.
- W1931451724 creator A5024266430 @default.
- W1931451724 date "1997-10-01" @default.
- W1931451724 modified "2023-09-24" @default.
- W1931451724 title "The Glutamate Receptor Subunit δ1 Is Highly Expressed in Hair Cells of the Auditory and Vestibular Systems" @default.
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- W1931451724 doi "https://doi.org/10.1523/jneurosci.17-19-07523.1997" @default.
- W1931451724 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573459" @default.
- W1931451724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9295397" @default.
- W1931451724 hasPublicationYear "1997" @default.
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