FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1931482718> ?p ?o ?g. }

• W1931482718 endingPage "650" @default.
• W1931482718 startingPage "645" @default.
• W1931482718 abstract "Experimental infections of human male volunteers with Neisseria gonorrhoeae have provided valuable insights into the early stages of gonorrheal disease. Bacterial variants expressing outer membrane opacity (Opa) proteins appear to be selected from the inoculum during a period in which total recoverable numbers of bacteria decrease rapidly. This apparent survival advantage occurs simultaneously with the onset of an inflammatory response, characterized by local production of interleukin 6 (IL-6) and IL-8 and the appearance of leukocytes in urine. Since the inflammatory response may also result in the presence of serum factors on the mucosal surface, we investigated the possibility that killing in normal human serum (NHS) leads to the selection of Opa+ variants. We therefore studied killing of separate populations and mixtures of Opa- and Opa+ N. gonorrhoeae MS11mk in NHS. Expression of an Opa protein conferred a survival advantage upon the organism; i.e., the Opa+ variants were more serum resistant than their isogenic Opa- counterparts, resulting in a selection for Opa+ phenotypes when a mixture of Opa+ and Opa- gonococci (GC) was exposed to submaximal doses of NHS. This selection was observed in three different lipooligosaccharide (LOS) backgrounds, indicating that it was not due to a difference in LOS expression between Opa- and Opa+ phenotypes. Incubation in NHS of sialylated GC resulted in a similar selection for Opa+ variants. The presence of normal human urine during the serum killing assay had no effect on the selection phenomenon but drastically depleted NHS of bactericidal activity, which was found to be at least partly due to complement inhibition. The results suggest that serum killing may contribute to the transition from Opa- to Opa+ phenotypes during the early stages of infection of the male urethra." @default.
• W1931482718 created "2016-06-24" @default.
• W1931482718 creator A5016187102 @default.
• W1931482718 creator A5077894116 @default.
• W1931482718 creator A5080416218 @default.
• W1931482718 date "1997-02-01" @default.
• W1931482718 modified "2023-10-15" @default.
• W1931482718 title "Selection of Opa+ Neisseria gonorrhoeae by limited availability of normal human serum" @default.
• W1931482718 cites W1781864281 @default.
• W1931482718 cites W1864976436 @default.
• W1931482718 cites W1910127275 @default.
• W1931482718 cites W1951083500 @default.
• W1931482718 cites W1978090129 @default.
• W1931482718 cites W1987107697 @default.
• W1931482718 cites W1994790587 @default.
• W1931482718 cites W2012113843 @default.
• W1931482718 cites W2017597673 @default.
• W1931482718 cites W2020490222 @default.
• W1931482718 cites W2027908852 @default.
• W1931482718 cites W2031316099 @default.
• W1931482718 cites W2041864654 @default.
• W1931482718 cites W2056171038 @default.
• W1931482718 cites W2064603910 @default.
• W1931482718 cites W2086555070 @default.
• W1931482718 cites W2116206391 @default.
• W1931482718 cites W2119429618 @default.
• W1931482718 cites W2135420926 @default.
• W1931482718 cites W2143929469 @default.
• W1931482718 cites W2144379257 @default.
• W1931482718 cites W2156130223 @default.
• W1931482718 cites W2157479292 @default.
• W1931482718 cites W2165691041 @default.
• W1931482718 cites W2174380698 @default.
• W1931482718 cites W2319628067 @default.
• W1931482718 cites W2410476973 @default.
• W1931482718 doi "https://doi.org/10.1128/iai.65.2.645-650.1997" @default.
• W1931482718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/176109" @default.
• W1931482718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9009326" @default.
• W1931482718 hasPublicationYear "1997" @default.
• W1931482718 type Work @default.
• W1931482718 sameAs 1931482718 @default.
• W1931482718 citedByCount "28" @default.
• W1931482718 countsByYear W19314827182013 @default.
• W1931482718 countsByYear W19314827182014 @default.
• W1931482718 countsByYear W19314827182015 @default.
• W1931482718 countsByYear W19314827182017 @default.
• W1931482718 countsByYear W19314827182020 @default.
• W1931482718 crossrefType "journal-article" @default.
• W1931482718 hasAuthorship W1931482718A5016187102 @default.
• W1931482718 hasAuthorship W1931482718A5077894116 @default.
• W1931482718 hasAuthorship W1931482718A5080416218 @default.
• W1931482718 hasBestOaLocation W19314827181 @default.
• W1931482718 hasConcept C104317684 @default.
• W1931482718 hasConcept C127716648 @default.
• W1931482718 hasConcept C143701427 @default.
• W1931482718 hasConcept C154945302 @default.
• W1931482718 hasConcept C203014093 @default.
• W1931482718 hasConcept C25642318 @default.
• W1931482718 hasConcept C2776983828 @default.
• W1931482718 hasConcept C2779166590 @default.
• W1931482718 hasConcept C41008148 @default.
• W1931482718 hasConcept C501593827 @default.
• W1931482718 hasConcept C54355233 @default.
• W1931482718 hasConcept C55493867 @default.
• W1931482718 hasConcept C81917197 @default.
• W1931482718 hasConcept C86803240 @default.
• W1931482718 hasConcept C89423630 @default.
• W1931482718 hasConceptScore W1931482718C104317684 @default.
• W1931482718 hasConceptScore W1931482718C127716648 @default.
• W1931482718 hasConceptScore W1931482718C143701427 @default.
• W1931482718 hasConceptScore W1931482718C154945302 @default.
• W1931482718 hasConceptScore W1931482718C203014093 @default.
• W1931482718 hasConceptScore W1931482718C25642318 @default.
• W1931482718 hasConceptScore W1931482718C2776983828 @default.
• W1931482718 hasConceptScore W1931482718C2779166590 @default.
• W1931482718 hasConceptScore W1931482718C41008148 @default.
• W1931482718 hasConceptScore W1931482718C501593827 @default.
• W1931482718 hasConceptScore W1931482718C54355233 @default.
• W1931482718 hasConceptScore W1931482718C55493867 @default.
• W1931482718 hasConceptScore W1931482718C81917197 @default.
• W1931482718 hasConceptScore W1931482718C86803240 @default.
• W1931482718 hasConceptScore W1931482718C89423630 @default.
• W1931482718 hasIssue "2" @default.
• W1931482718 hasLocation W19314827181 @default.
• W1931482718 hasLocation W19314827182 @default.
• W1931482718 hasLocation W19314827183 @default.
• W1931482718 hasOpenAccess W1931482718 @default.
• W1931482718 hasPrimaryLocation W19314827181 @default.
• W1931482718 hasRelatedWork W1560859789 @default.
• W1931482718 hasRelatedWork W1903554784 @default.
• W1931482718 hasRelatedWork W1980435337 @default.
• W1931482718 hasRelatedWork W1981931122 @default.
• W1931482718 hasRelatedWork W2038606227 @default.
• W1931482718 hasRelatedWork W2110818245 @default.
• W1931482718 hasRelatedWork W2416749769 @default.
• W1931482718 hasRelatedWork W2902637218 @default.
• W1931482718 hasRelatedWork W3114965951 @default.
• W1931482718 hasRelatedWork W4281258317 @default.

• next