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• W1931583840 abstract "Syntaxin 1 is a SNARE protein that plays a central role in synaptic vesicle (SV) exocytosis. We generated an antibody that specifically recognizes a casein kinase II-mediated phosphorylation on serine-14 of syntaxin 1. In this report we show that this phosphorylation occurs in vivo and is developmentally regulated in the rat brain, rising to a level of 40% of the total syntaxin in adult animals. Phosphorylated syntaxin is preferentially associated with SNAP-25 and localizes to discrete domains of the axonal plasma membrane that do not colocalize with pools of synaptic vesicles. These phosphosyntaxin domains may define fusion sites for a novel class of vesicles outside classical active zones." @default.
• W1931583840 created "2016-06-24" @default.
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• W1931583840 date "2000-06-15" @default.
• W1931583840 modified "2023-10-03" @default.
• W1931583840 title "Phosphorylated Syntaxin 1 Is Localized to Discrete Domains Along a Subset of Axons" @default.
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• W1931583840 doi "https://doi.org/10.1523/jneurosci.20-12-04535.2000" @default.
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