Matches in SemOpenAlex for { <https://semopenalex.org/work/W1931592110> ?p ?o ?g. }
- W1931592110 endingPage "3983" @default.
- W1931592110 startingPage "3970" @default.
- W1931592110 abstract "Abstract Endosomes have important roles in intracellular signal transduction as a sorting platform. Signaling cascades from TLR engagement to IRF3-dependent gene transcription rely on endosomes, yet the proteins that specifically recruit IRF3-activating molecules to them are poorly defined. We show that adaptor protein containing a pleckstrin-homology domain, a phosphotyrosine-binding domain, and a leucine zipper motif (APPL)1, an early endosomal protein, is required for both TRIF- and retinoic acid–inducible gene 1–dependent signaling cascades to induce IRF3 activation. APPL1, but not early endosome Ag 1, deficiency impairs IRF3 target gene expression upon engagement of both TLR3 and TLR4 pathways, as well as in H1N1-infected macrophages. The IRF3-phosphorylating kinases TBK1 and IKKε are recruited to APPL1 endosomes in LPS-stimulated macrophages. Interestingly, APPL1 undergoes proteasome-mediated degradation through ERK1/2 to turn off signaling. APPL1 degradation is blocked when signaling through the endosome is inhibited by chloroquine or dynasore. Therefore, APPL1 endosomes are critical for IRF3-dependent gene expression in response to some viral and bacterial infections in macrophages. Those signaling pathways involve the signal-induced degradation of APPL1 to prevent aberrant IRF3-dependent gene expression linked to immune diseases." @default.
- W1931592110 created "2016-06-24" @default.
- W1931592110 creator A5005471754 @default.
- W1931592110 creator A5009658799 @default.
- W1931592110 creator A5019799355 @default.
- W1931592110 creator A5023433222 @default.
- W1931592110 creator A5026606268 @default.
- W1931592110 creator A5028914425 @default.
- W1931592110 creator A5030325551 @default.
- W1931592110 creator A5043931594 @default.
- W1931592110 creator A5070605844 @default.
- W1931592110 creator A5076624861 @default.
- W1931592110 creator A5078000054 @default.
- W1931592110 date "2015-04-15" @default.
- W1931592110 modified "2023-09-24" @default.
- W1931592110 title "A Role for APPL1 in TLR3/4-Dependent TBK1 and IKKε Activation in Macrophages" @default.
- W1931592110 cites W1524640351 @default.
- W1931592110 cites W1591714343 @default.
- W1931592110 cites W1642847216 @default.
- W1931592110 cites W1667782349 @default.
- W1931592110 cites W1962511056 @default.
- W1931592110 cites W1964442232 @default.
- W1931592110 cites W1965205650 @default.
- W1931592110 cites W1969776705 @default.
- W1931592110 cites W1974164343 @default.
- W1931592110 cites W1975510716 @default.
- W1931592110 cites W1980918455 @default.
- W1931592110 cites W1983924398 @default.
- W1931592110 cites W1991731944 @default.
- W1931592110 cites W1992342289 @default.
- W1931592110 cites W1994942139 @default.
- W1931592110 cites W2005626121 @default.
- W1931592110 cites W2008969317 @default.
- W1931592110 cites W2009708031 @default.
- W1931592110 cites W2028575270 @default.
- W1931592110 cites W2031295480 @default.
- W1931592110 cites W2050624870 @default.
- W1931592110 cites W2054807667 @default.
- W1931592110 cites W2067678108 @default.
- W1931592110 cites W2068844394 @default.
- W1931592110 cites W2076361525 @default.
- W1931592110 cites W2079687293 @default.
- W1931592110 cites W2084224574 @default.
- W1931592110 cites W2084880831 @default.
- W1931592110 cites W2087661112 @default.
- W1931592110 cites W2091479071 @default.
- W1931592110 cites W2095249521 @default.
- W1931592110 cites W2095250075 @default.
- W1931592110 cites W2096837432 @default.
- W1931592110 cites W2103500013 @default.
- W1931592110 cites W2108784668 @default.
- W1931592110 cites W2109534473 @default.
- W1931592110 cites W2111428445 @default.
- W1931592110 cites W2111503158 @default.
- W1931592110 cites W2112032807 @default.
- W1931592110 cites W2115185894 @default.
- W1931592110 cites W2116097926 @default.
- W1931592110 cites W2129319296 @default.
- W1931592110 cites W2129890352 @default.
- W1931592110 cites W2131026449 @default.
- W1931592110 cites W2134077483 @default.
- W1931592110 cites W2135012473 @default.
- W1931592110 cites W2140820666 @default.
- W1931592110 cites W2144148464 @default.
- W1931592110 cites W2144787399 @default.
- W1931592110 cites W2147140524 @default.
- W1931592110 cites W2151687527 @default.
- W1931592110 cites W2156171182 @default.
- W1931592110 cites W2156948997 @default.
- W1931592110 cites W2164087707 @default.
- W1931592110 cites W2168531121 @default.
- W1931592110 doi "https://doi.org/10.4049/jimmunol.1401614" @default.
- W1931592110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25780039" @default.
- W1931592110 hasPublicationYear "2015" @default.
- W1931592110 type Work @default.
- W1931592110 sameAs 1931592110 @default.
- W1931592110 citedByCount "15" @default.
- W1931592110 countsByYear W19315921102015 @default.
- W1931592110 countsByYear W19315921102016 @default.
- W1931592110 countsByYear W19315921102017 @default.
- W1931592110 countsByYear W19315921102019 @default.
- W1931592110 countsByYear W19315921102020 @default.
- W1931592110 countsByYear W19315921102021 @default.
- W1931592110 countsByYear W19315921102022 @default.
- W1931592110 countsByYear W19315921102023 @default.
- W1931592110 crossrefType "journal-article" @default.
- W1931592110 hasAuthorship W1931592110A5005471754 @default.
- W1931592110 hasAuthorship W1931592110A5009658799 @default.
- W1931592110 hasAuthorship W1931592110A5019799355 @default.
- W1931592110 hasAuthorship W1931592110A5023433222 @default.
- W1931592110 hasAuthorship W1931592110A5026606268 @default.
- W1931592110 hasAuthorship W1931592110A5028914425 @default.
- W1931592110 hasAuthorship W1931592110A5030325551 @default.
- W1931592110 hasAuthorship W1931592110A5043931594 @default.
- W1931592110 hasAuthorship W1931592110A5070605844 @default.
- W1931592110 hasAuthorship W1931592110A5076624861 @default.
- W1931592110 hasAuthorship W1931592110A5078000054 @default.
- W1931592110 hasBestOaLocation W19315921101 @default.