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• W1931593342 endingPage "1109" @default.
• W1931593342 startingPage "1096" @default.
• W1931593342 abstract "Abstract In this Standard of Laboratory Practice we recommend guidelines for therapeutic monitoring of cardiac drugs. Cardiac drugs are primarily used for treatment of angina, arrhythmias, and congestive heart failure. Digoxin, used in congestive heart failure, is widely prescribed and therapeutically monitored. Monitoring and use of antiarrhythmics such as disopyramide and lidocaine have been steadily declining. Immunoassay techniques are currently the most popular methods for measuring cardiac drugs. Several reasons make measurement of cardiac drugs in serum important: their narrow therapeutic index, similarity in clinical complications and presentation of under- and overmedicated patients, need for dosage adjustments, and confirmation of patient compliance. Monitoring may also be necessary in other circumstances, such as assessment of acetylator phenotypes. We present recommendations for measuring digoxin, quinidine, procainamide (and N-acetylprocainamide), lidocaine, and flecainide. We discuss guidelines for measuring unbound digoxin in the presence of an antidote (Fab fragments), for characterizing the impact of digoxin-like immunoreactive factor (DLIF) and other cross-reactants on immunoassays, and for monitoring the unbound (free fraction) of drugs that bind to α1-acid glycoprotein. We also discuss logistic, clinical, hospital, and laboratory practice guidelines needed for implementation of a successful therapeutic drug monitoring service for cardiac drugs." @default.
• W1931593342 created "2016-06-24" @default.
• W1931593342 creator A5011293667 @default.
• W1931593342 creator A5012284116 @default.
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• W1931593342 date "1998-05-01" @default.
• W1931593342 modified "2023-09-24" @default.
• W1931593342 title "Standards of laboratory practice: cardiac drug monitoring" @default.
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• W1931593342 doi "https://doi.org/10.1093/clinchem/44.5.1096" @default.
• W1931593342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9590394" @default.
• W1931593342 hasPublicationYear "1998" @default.
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