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- W1931776714 abstract "Introduction: Extreme preterm (EP) birth is associated with acinar developmental alterations, potentially influencing lung diffusing capacity (DLCO) and gas exchange. Techniques of measurement are complex and feasibility in children needs to be addressed.Aims: To study repeatability of DLCO in children and young adults, and to compare results of subjects born EP and at term in two different decades.Methods: Two area-based cohorts of subjects born at gestational age (GA) ≤ 28 weeks or with birth weight (BW) ≤ 1000 grams in the two periods 1991-1992 (n=35) and 1982-1985 (n=46) and matched controls born at term performed single-breath DLCO tests twice within two weeks. Mean ages (SD) were 10.6 (0.4) and 17.7 (1.2) years.Results: The coefficient of variation for intersession measurements of DLCO for subjects born preterm and at term in the 1991-92 and 1982-85 birth-cohorts were 8.2 and 7.7%, and 9.5 and 7.6%, respectively. EP birth was associated with significantly reduced height adjusted DLCO and with lower KCO**. Deficits were similar in the two birth-cohorts (test of interaction, p = 0.410).View this table:Conclusions: Repeatability of DLCO was acceptable for all subgroups. Compared to controls born at term, lung diffusion capacity was significantly and similarly reduced for subjects born preterm in the two decades studied." @default.
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- W1931776714 date "2011-09-01" @default.
- W1931776714 modified "2023-09-24" @default.
- W1931776714 title "Single-breath lung diffusion capacity for carbon monoxide in children and young adults born extremely preterm" @default.
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