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• W1931861644 abstract "Objectives To assess the value of the ultrasound (US) attenuation index for noninvasive estimation of hepatic steatosis and determine its optimal cutoff value for severe steatosis in potential living liver donors. Methods Two hundred forty potential donors underwent US-guided biopsy. The target site was scanned at 4 and 8 MHz. On the sonogram, the observer drew 3 × 3-mm square regions of interest in superficial (3-cm) and deep (5-cm) areas. The attenuation index was defined as the difference between superficial and deep echogenicity/superficial echogenicity × 100. On biopsy specimens, replacement of hepatic parenchyma was evaluated on a percentage scale. Severe steatosis was defined as macrovesicular fatty change of 30% or greater. Spearman rank correlation (ρ) was used to determine correlation coefficients between the attenuation index and steatosis degree; receiver operating characteristic analysis was performed to determine the optimal attenuation index cutoff value for severe steatosis. Results The median steatosis degree was 3% (interquartile range [IQR], 0%–10%). Severe steatosis was found in 10 donors. The attenuation index ranged from –27.4 to 36.6 (median, 4.0; IQR, –1.6–10.4) at 4 MHz and –18.0 to 78.1 (median, 14.5; IQR, 7.2–21.9) at 8 MHz. There was a minimal positive correlation between steatosis and the attenuation index at 4 MHz (total steatosis: ρ = 0.339; P < .001; macrovesicular steatosis: ρ = 0.360; P < .001). However, there was a significant moderate correlation between steatosis and the attenuation index at 8 MHz (total steatosis: ρ = 0.669; P < .001; macrovesicular steatosis: ρ = 0.645; P < .001). The optimal attenuation index cutoff value for severe steatosis at 8 MHz was 31.0. Conclusions The US attenuation index at 8 MHz is a useful indicator for noninvasive quantitative estimation of hepatic steatosis and diagnosis of severe steatosis in potential living liver donors." @default.
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• W1931861644 date "2013-02-01" @default.
• W1931861644 modified "2023-09-28" @default.
• W1931861644 title "Value of the Ultrasound Attenuation Index for Noninvasive Quantitative Estimation of Hepatic Steatosis" @default.
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• W1931861644 doi "https://doi.org/10.7863/jum.2013.32.2.229" @default.
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