Matches in SemOpenAlex for { <https://semopenalex.org/work/W193199561> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W193199561 abstract "The role of exogenous carbamoyl-amino acids in protein biosynthesis has been examined in vitro using a mixture of UC amino acids to label newly synthesized protein in human reticulocyte rich (8-18%) peripheral blood. Aliquots of the radiolabeled newly synthesized protein were acid precipitated, washed and the radioactivity measured. Control samples which measured the synthetic capacity of the blood were aliquots of the same blood- UC amino acid mixture without added carbamoyl-amino acids or cyanate. N-carbamoyl leucine alone or a 3 N-carbamoyl amino acid mixture of leucine, aspartic acid and tyrosine were used to test inhibition of protein synthesis. Also carbamoyl-amino acids were synthesized using cyanate and Pierce hydrolyzate amino acid calibration standards or the mixture of UC amino acids. In this system the carbamoylation of endogenous amino acids by cyanate up to 8 mol/100 l showed a linear decrease in protein synthesis with time which is inversely related to the cyanate concentration. At greater cyanate levels the inhibition of protein synthesis reaches a plateau. When N-carbamoyl-amino acids only are present there is about a 50% decrease in the UC protein at 30 minutes as compared to the synthesis of UC protein without N-carbamoyl-amino acids. These results indicate that the presencemore » of carbamoyl-amino acids interferes with protein synthesis.« less" @default.
- W193199561 created "2016-06-24" @default.
- W193199561 creator A5063129145 @default.
- W193199561 creator A5090045705 @default.
- W193199561 date "1987-05-01" @default.
- W193199561 modified "2023-09-24" @default.
- W193199561 title "Protein synthesis in the presence of carbamoyl-amino acids" @default.
- W193199561 hasPublicationYear "1987" @default.
- W193199561 type Work @default.
- W193199561 sameAs 193199561 @default.
- W193199561 citedByCount "0" @default.
- W193199561 crossrefType "journal-article" @default.
- W193199561 hasAuthorship W193199561A5063129145 @default.
- W193199561 hasAuthorship W193199561A5090045705 @default.
- W193199561 hasConcept C178790620 @default.
- W193199561 hasConcept C185592680 @default.
- W193199561 hasConcept C2776165026 @default.
- W193199561 hasConcept C2776580952 @default.
- W193199561 hasConcept C2779195922 @default.
- W193199561 hasConcept C3675279 @default.
- W193199561 hasConcept C515207424 @default.
- W193199561 hasConcept C55493867 @default.
- W193199561 hasConceptScore W193199561C178790620 @default.
- W193199561 hasConceptScore W193199561C185592680 @default.
- W193199561 hasConceptScore W193199561C2776165026 @default.
- W193199561 hasConceptScore W193199561C2776580952 @default.
- W193199561 hasConceptScore W193199561C2779195922 @default.
- W193199561 hasConceptScore W193199561C3675279 @default.
- W193199561 hasConceptScore W193199561C515207424 @default.
- W193199561 hasConceptScore W193199561C55493867 @default.
- W193199561 hasLocation W1931995611 @default.
- W193199561 hasOpenAccess W193199561 @default.
- W193199561 hasPrimaryLocation W1931995611 @default.
- W193199561 hasRelatedWork W1514181378 @default.
- W193199561 hasRelatedWork W1541059747 @default.
- W193199561 hasRelatedWork W1572649633 @default.
- W193199561 hasRelatedWork W1678808945 @default.
- W193199561 hasRelatedWork W1855370269 @default.
- W193199561 hasRelatedWork W1965880642 @default.
- W193199561 hasRelatedWork W1966647308 @default.
- W193199561 hasRelatedWork W1967257225 @default.
- W193199561 hasRelatedWork W1976840737 @default.
- W193199561 hasRelatedWork W1990455378 @default.
- W193199561 hasRelatedWork W2000877296 @default.
- W193199561 hasRelatedWork W2011360236 @default.
- W193199561 hasRelatedWork W2051786427 @default.
- W193199561 hasRelatedWork W2079619466 @default.
- W193199561 hasRelatedWork W2085362216 @default.
- W193199561 hasRelatedWork W2165811080 @default.
- W193199561 hasRelatedWork W232234330 @default.
- W193199561 hasRelatedWork W2327261057 @default.
- W193199561 hasRelatedWork W2993009314 @default.
- W193199561 hasRelatedWork W57618302 @default.
- W193199561 isParatext "false" @default.
- W193199561 isRetracted "false" @default.
- W193199561 magId "193199561" @default.
- W193199561 workType "article" @default.