FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1932095716> ?p ?o ?g. }

• W1932095716 endingPage "693" @default.
• W1932095716 startingPage "679" @default.
• W1932095716 abstract "Interferon-induced transmembrane protein 3 (IFITM3) ıplays a crucial role in the antiviral responses of Type I interferons (IFNs). The role of IFITM3 in the central nervous system (CNS) is, however, largely unknown, despite the fact that its expression is increased in the brains of patients with neurologic and neuropsychiatric diseases. Here, we show the role of IFITM3 in long-lasting neuronal impairments in mice following polyriboinosinic-polyribocytidylic acid (polyI:C, a synthetic double-stranded RNA)-induced immune challenge during the early stages of development. We found that the induction of IFITM3 expression in the brain of mice treated with polyI:C was observed only in astrocytes. Cultured astrocytes were activated by polyI:C treatment, leading to an increase in the mRNA levels of inflammatory cytokines as well as Ifitm3. When cultured neurons were treated with the conditioned medium of polyI:C-treated astrocytes (polyI:C-ACM), neurite development was impaired. These polyI:C-ACM-induced neurodevelopmental abnormalities were alleviated by ifitm3(-/-) astrocyte-conditioned medium. Furthermore, decreases of MAP2 expression, spine density, and dendrite complexity in the frontal cortex as well as memory impairment were evident in polyI:C-treated wild-type mice, but such neuronal impairments were not observed in ifitm3(-) (/) (-) mice. We also found that IFITM3 proteins were localized to the early endosomes of astrocytes following polyI:C treatment and reduced endocytic activity. These findings suggest that the induction of IFITM3 expression in astrocytes by the activation of the innate immune system during the early stages of development has non-cell autonomous effects that affect subsequent neurodevelopment, leading to neuropathological impairments and brain dysfunction, by impairing endocytosis in astrocytes." @default.
• W1932095716 created "2016-06-24" @default.
• W1932095716 creator A5003596492 @default.
• W1932095716 creator A5012487815 @default.
• W1932095716 creator A5017258609 @default.
• W1932095716 creator A5019154340 @default.
• W1932095716 creator A5021300056 @default.
• W1932095716 creator A5022133891 @default.
• W1932095716 creator A5023373285 @default.
• W1932095716 creator A5025386235 @default.
• W1932095716 creator A5030309677 @default.
• W1932095716 creator A5040522826 @default.
• W1932095716 creator A5055747865 @default.
• W1932095716 creator A5061371609 @default.
• W1932095716 creator A5069018183 @default.
• W1932095716 creator A5070060856 @default.
• W1932095716 creator A5074635182 @default.
• W1932095716 creator A5085053419 @default.
• W1932095716 creator A5086048520 @default.
• W1932095716 date "2013-02-04" @default.
• W1932095716 modified "2023-09-28" @default.
• W1932095716 title "Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice" @default.
• W1932095716 cites W1564192489 @default.
• W1932095716 cites W1759917824 @default.
• W1932095716 cites W1885585690 @default.
• W1932095716 cites W1964358779 @default.
• W1932095716 cites W1967900102 @default.
• W1932095716 cites W1969117282 @default.
• W1932095716 cites W1970028828 @default.
• W1932095716 cites W1973478979 @default.
• W1932095716 cites W1973941982 @default.
• W1932095716 cites W1978319794 @default.
• W1932095716 cites W1979582699 @default.
• W1932095716 cites W1979919872 @default.
• W1932095716 cites W1981971321 @default.
• W1932095716 cites W1984120803 @default.
• W1932095716 cites W1991942710 @default.
• W1932095716 cites W1998058878 @default.
• W1932095716 cites W2003988251 @default.
• W1932095716 cites W2005392387 @default.
• W1932095716 cites W2009640362 @default.
• W1932095716 cites W2015640363 @default.
• W1932095716 cites W2016111184 @default.
• W1932095716 cites W2030912492 @default.
• W1932095716 cites W2034175657 @default.
• W1932095716 cites W2034324831 @default.
• W1932095716 cites W2040268226 @default.
• W1932095716 cites W2046133662 @default.
• W1932095716 cites W2048333374 @default.
• W1932095716 cites W2050348182 @default.
• W1932095716 cites W2051156300 @default.
• W1932095716 cites W2055677723 @default.
• W1932095716 cites W2059015272 @default.
• W1932095716 cites W2059586821 @default.
• W1932095716 cites W2070705691 @default.
• W1932095716 cites W2076134341 @default.
• W1932095716 cites W2077620427 @default.
• W1932095716 cites W2078646756 @default.
• W1932095716 cites W2079320514 @default.
• W1932095716 cites W2079733602 @default.
• W1932095716 cites W2084050149 @default.
• W1932095716 cites W2092805924 @default.
• W1932095716 cites W2100986512 @default.
• W1932095716 cites W2109491705 @default.
• W1932095716 cites W2114421191 @default.
• W1932095716 cites W2121009504 @default.
• W1932095716 cites W2125566625 @default.
• W1932095716 cites W2135264287 @default.
• W1932095716 cites W2139540961 @default.
• W1932095716 cites W2140813286 @default.
• W1932095716 cites W2145990658 @default.
• W1932095716 cites W2146768128 @default.
• W1932095716 cites W2163759450 @default.
• W1932095716 cites W2165456024 @default.
• W1932095716 cites W2315937070 @default.
• W1932095716 doi "https://doi.org/10.1002/glia.22461" @default.
• W1932095716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7165731" @default.
• W1932095716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23382131" @default.
• W1932095716 hasPublicationYear "2013" @default.
• W1932095716 type Work @default.
• W1932095716 sameAs 1932095716 @default.
• W1932095716 citedByCount "49" @default.
• W1932095716 countsByYear W19320957162013 @default.
• W1932095716 countsByYear W19320957162014 @default.
• W1932095716 countsByYear W19320957162015 @default.
• W1932095716 countsByYear W19320957162016 @default.
• W1932095716 countsByYear W19320957162017 @default.
• W1932095716 countsByYear W19320957162018 @default.
• W1932095716 countsByYear W19320957162019 @default.
• W1932095716 countsByYear W19320957162020 @default.
• W1932095716 countsByYear W19320957162021 @default.
• W1932095716 countsByYear W19320957162022 @default.
• W1932095716 countsByYear W19320957162023 @default.
• W1932095716 crossrefType "journal-article" @default.
• W1932095716 hasAuthorship W1932095716A5003596492 @default.
• W1932095716 hasAuthorship W1932095716A5012487815 @default.
• W1932095716 hasAuthorship W1932095716A5017258609 @default.
• W1932095716 hasAuthorship W1932095716A5019154340 @default.

• next