FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1932270904> ?p ?o ?g. }

• W1932270904 endingPage "1291" @default.
• W1932270904 startingPage "1278" @default.
• W1932270904 abstract "Introduction The roles of testosterone and orchiectomy on male bladder subjected to ischemic/reperfusion (I/R) injuries received little attention. To fill this gap, the present study intended to examine testosterone and orchiectomy effects on male rabbits subjected to I/R damages. Aim To elucidate the effects of testosterone and orchiectomy on contractile response, bladder morphology, interstitial fibrosis, and oxidative stress in male rabbit bladder subjected to I/R surgery. Methods Male New Zealand rabbits were distributed into five groups as follows: Group 1 received sham surgical procedure. In group 2, I/R surgery was performed. In group 3, testosterone (100 μg/kg/day) was intramuscularly injected prior to I/R surgery. In group 4, orchiectomy was performed prior to I/R surgery. In group 5, orchiectomy was performed with subsequent testosterone administration, followed by I/R surgery. All the rabbits were euthanized 7 days after I/R. Comparative studies were analyzed to elucidate the effects of testosterone and orchiectomy on bladder dysfunction subjected to I/R injuries. Main Outcome Measures Bladder contractile function was evaluated. Masson's trichrome staining and immunohistochemical studies were performed to evaluate bladder morphology and intramural nerve terminals. Western blotting was examined to investigate the expressions of fibrosis and oxidative stress markers. Results I/R surgery significantly decreased bladder contractility in response to various stimulations with and without testosterone treatment. I/R damages decreased bladder nerve density with and without testosterone. The expressions of fibrosis and oxidative stress‐related proteins were increased by I/R injuries with or without testosterone treatment. Testosterone depletion significantly decreased the expressions of transforming growth factor‐β and fibronectin expressions after I/R injury. Supraphysiological testosterone treatment after orchiectomy greatly increased the expressions of these fibrosis proteins; however, orchiectomy alone ameliorated I/R injuries. Conclusions Testosterone treatment or orchiectomy affected I/R‐induced bladder damages in male rabbits. Orchiectomy decreased the level of fibrosis and oxidative stress markers and increased neurofilament densities. Supraphysiological exogenous testosterone administration after orchiectomy further exacerbated such detrimental effects of I/R." @default.
• W1932270904 created "2016-06-24" @default.
• W1932270904 creator A5003762652 @default.
• W1932270904 creator A5007536111 @default.
• W1932270904 creator A5014733297 @default.
• W1932270904 creator A5020300808 @default.
• W1932270904 creator A5042687042 @default.
• W1932270904 creator A5063366408 @default.
• W1932270904 creator A5070782518 @default.
• W1932270904 creator A5089987716 @default.
• W1932270904 creator A5079830019 @default.
• W1932270904 date "2013-05-01" @default.
• W1932270904 modified "2023-10-07" @default.
• W1932270904 title "Effects of Supraphysiological Testosterone Treatment and Orchiectomy on Ischemia/Reperfusion‐Induced Bladder Dysfunction in Male Rabbits" @default.
• W1932270904 cites W1848898801 @default.
• W1932270904 cites W1897990939 @default.
• W1932270904 cites W1954074806 @default.
• W1932270904 cites W1965582720 @default.
• W1932270904 cites W1965805135 @default.
• W1932270904 cites W1972624539 @default.
• W1932270904 cites W1983846424 @default.
• W1932270904 cites W1986949112 @default.
• W1932270904 cites W1988947312 @default.
• W1932270904 cites W2008182039 @default.
• W1932270904 cites W2011374440 @default.
• W1932270904 cites W2014183575 @default.
• W1932270904 cites W2015484640 @default.
• W1932270904 cites W2018307827 @default.
• W1932270904 cites W2018368054 @default.
• W1932270904 cites W2026135073 @default.
• W1932270904 cites W2031773074 @default.
• W1932270904 cites W2032925403 @default.
• W1932270904 cites W2035001907 @default.
• W1932270904 cites W2042044295 @default.
• W1932270904 cites W2047920823 @default.
• W1932270904 cites W2049881120 @default.
• W1932270904 cites W2050614537 @default.
• W1932270904 cites W2057386428 @default.
• W1932270904 cites W2060414700 @default.
• W1932270904 cites W2061286597 @default.
• W1932270904 cites W2066946777 @default.
• W1932270904 cites W2069927388 @default.
• W1932270904 cites W2073729932 @default.
• W1932270904 cites W2075089760 @default.
• W1932270904 cites W2075958682 @default.
• W1932270904 cites W2077556773 @default.
• W1932270904 cites W2080371603 @default.
• W1932270904 cites W2081710331 @default.
• W1932270904 cites W2082384828 @default.
• W1932270904 cites W2082793300 @default.
• W1932270904 cites W2088233707 @default.
• W1932270904 cites W2094969891 @default.
• W1932270904 cites W2098798681 @default.
• W1932270904 cites W2106039105 @default.
• W1932270904 cites W2119968980 @default.
• W1932270904 cites W2123421042 @default.
• W1932270904 cites W2129120791 @default.
• W1932270904 cites W2151369191 @default.
• W1932270904 cites W2151455160 @default.
• W1932270904 cites W2162271532 @default.
• W1932270904 cites W2165997593 @default.
• W1932270904 doi "https://doi.org/10.1111/jsm.12104" @default.
• W1932270904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23445432" @default.
• W1932270904 hasPublicationYear "2013" @default.
• W1932270904 type Work @default.
• W1932270904 sameAs 1932270904 @default.
• W1932270904 citedByCount "6" @default.
• W1932270904 countsByYear W19322709042014 @default.
• W1932270904 countsByYear W19322709042015 @default.
• W1932270904 countsByYear W19322709042016 @default.
• W1932270904 countsByYear W19322709042017 @default.
• W1932270904 countsByYear W19322709042021 @default.
• W1932270904 countsByYear W19322709042022 @default.
• W1932270904 crossrefType "journal-article" @default.
• W1932270904 hasAuthorship W1932270904A5003762652 @default.
• W1932270904 hasAuthorship W1932270904A5007536111 @default.
• W1932270904 hasAuthorship W1932270904A5014733297 @default.
• W1932270904 hasAuthorship W1932270904A5020300808 @default.
• W1932270904 hasAuthorship W1932270904A5042687042 @default.
• W1932270904 hasAuthorship W1932270904A5063366408 @default.
• W1932270904 hasAuthorship W1932270904A5070782518 @default.
• W1932270904 hasAuthorship W1932270904A5079830019 @default.
• W1932270904 hasAuthorship W1932270904A5089987716 @default.
• W1932270904 hasConcept C126322002 @default.
• W1932270904 hasConcept C126894567 @default.
• W1932270904 hasConcept C134018914 @default.
• W1932270904 hasConcept C142724271 @default.
• W1932270904 hasConcept C204787440 @default.
• W1932270904 hasConcept C2775961468 @default.
• W1932270904 hasConcept C2776151105 @default.
• W1932270904 hasConcept C2779279991 @default.
• W1932270904 hasConcept C2780559512 @default.
• W1932270904 hasConcept C2781440318 @default.
• W1932270904 hasConcept C71924100 @default.
• W1932270904 hasConceptScore W1932270904C126322002 @default.
• W1932270904 hasConceptScore W1932270904C126894567 @default.
• W1932270904 hasConceptScore W1932270904C134018914 @default.
• W1932270904 hasConceptScore W1932270904C142724271 @default.

• next