Matches in SemOpenAlex for { <https://semopenalex.org/work/W193238672> ?p ?o ?g. }
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- W193238672 abstract "Background: Obestatin is a peptide potentially produced in the stomach, pancreas and testis. Recently, obestatin was reported as a novel adipocytokine and its levels were decreased in obese subjects. Objective: This study was designed to explore the probable effects of obestain peptide in modulating the adverse effects of obesity on gonadal functions with a trial to clarify some of the possible underlying mechanisms. Animals and methods: 64 wistar albino rats 21-day old (32 males and 32 females) were divided equally (8males and 8females) into 4 groups, group (Ia): Saline-vehicle treated normal fed group, group (Ib): Rats were fed a normal chow for 10 weeks then obestatin was i.p injected (1 nmol) daily for 10 days, group (IIa): Saline-vehicle treated high fat fed group and group (IIb): Rats were fed high fat diet for 10 weeks then injected i.p with obestatin (1 nmol) daily for 10 days. 5 days after the end of obestatin administration BMI and AC/TC ratio were calculated, serum glucose& insulin (with calculation of HOMA-IR), lipid profile, FSH, LH, estradiol, in addition to testosterone (in male rats), and progesterone (in female rats), were estimated, mesenteric fat, epididymal fat, periovarian fat, the right testes and ovaries, were weighed. The epididymes were used for the evaluation of sperm parameters. The testes and ovaries were processed for histopathological studies. Results: There was a significant (p<0.001) increase in the anthropometric parameters together with deterioration of metabolic and gonadal functions in high fat fed group (group IIa), while exogenous obestatin administration in (group IIb) resulted in: Significant decrease in the anthropometric parameters and the fat weight, significant decrease in insulin resistance (HOMA-IR) (p<0.001), significant increase in serum LH (p<0.001)&testosterone (p<0.01), sperm count (p<0.01) and motility (p<0.001) in male rats. Moreover, there was a significant increase in serum LH (p<0.05) & progesterone (p<0.05) and restoration of the regularity of the estrus cycle (p<0.0001) in female rats. Together with marked improvement in the gonadal histoarchitecture. Conclusions: It could be suggested that obestatin has a potential positive role against obesity-induced gonadal dysfunction, which may be due to its role in maintenance of glucose & insulin homeostasis, and/ or maintenance of gonadal hormonal function via indirect and/or direct effect on the gonad." @default.
- W193238672 created "2016-06-24" @default.
- W193238672 creator A5006872437 @default.
- W193238672 creator A5032844796 @default.
- W193238672 creator A5036430549 @default.
- W193238672 creator A5055725610 @default.
- W193238672 date "2014-01-01" @default.
- W193238672 modified "2023-09-27" @default.
- W193238672 title "Effect of Obestatin on Gonadal Functions in High Fat-fed Albino Rats" @default.
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