FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1932456596> ?p ?o ?g. }

• W1932456596 endingPage "141" @default.
• W1932456596 startingPage "132" @default.
• W1932456596 abstract "High-throughput individual diagnostic dose assessment is essential for medical management of radiation-exposed subjects after a mass casualty. Cytogenetic assays such as the Dicentric Chromosome Assay (DCA) are recognized as the gold standard by international regulatory authorities. DCA is a multi-step and multi-day bioassay. DCA, as described in the IAEA manual, can be used to assess dose up to 4-6 weeks post-exposure quite accurately but throughput is still a major issue and automation is very essential. The throughput is limited, both in terms of sample preparation as well as analysis of chromosome aberrations. Thus, there is a need to design and develop novel solutions that could utilize extensive laboratory automation for sample preparation, and bioinformatics approaches for chromosome-aberration analysis to overcome throughput issues. We have transitioned the bench-based cytogenetic DCA to a coherent process performing high-throughput automated biodosimetry for individual dose assessment ensuring quality control (QC) and quality assurance (QA) aspects in accordance with international harmonized protocols. A Laboratory Information Management System (LIMS) is designed, implemented and adapted to manage increased sample processing capacity, develop and maintain standard operating procedures (SOP) for robotic instruments, avoid data transcription errors during processing, and automate analysis of chromosome-aberrations using an image analysis platform. Our efforts described in this paper intend to bridge the current technological gaps and enhance the potential application of DCA for a dose-based stratification of subjects following a mass casualty. This paper describes one such potential integrated automated laboratory system and functional evolution of the classical DCA towards increasing critically needed throughput." @default.
• W1932456596 created "2016-06-24" @default.
• W1932456596 creator A5027209735 @default.
• W1932456596 creator A5033244305 @default.
• W1932456596 creator A5074511442 @default.
• W1932456596 date "2015-11-01" @default.
• W1932456596 modified "2023-10-01" @default.
• W1932456596 title "High-throughput sample processing and sample management; the functional evolution of classical cytogenetic assay towards automation." @default.
• W1932456596 cites W1998334548 @default.
• W1932456596 cites W1999663423 @default.
• W1932456596 cites W2000986507 @default.
• W1932456596 cites W2020711141 @default.
• W1932456596 cites W2024846405 @default.
• W1932456596 cites W2026751847 @default.
• W1932456596 cites W2031783394 @default.
• W1932456596 cites W2033846744 @default.
• W1932456596 cites W2037314608 @default.
• W1932456596 cites W2061152329 @default.
• W1932456596 cites W2061939793 @default.
• W1932456596 cites W2070624526 @default.
• W1932456596 cites W2074946397 @default.
• W1932456596 cites W2077343886 @default.
• W1932456596 cites W2077519181 @default.
• W1932456596 cites W2092926610 @default.
• W1932456596 cites W2094161519 @default.
• W1932456596 cites W2102743607 @default.
• W1932456596 cites W2109885006 @default.
• W1932456596 cites W2134010239 @default.
• W1932456596 cites W2148936748 @default.
• W1932456596 cites W2169776852 @default.
• W1932456596 doi "https://doi.org/10.1016/j.mrgentox.2015.07.011" @default.
• W1932456596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26520383" @default.
• W1932456596 hasPublicationYear "2015" @default.
• W1932456596 type Work @default.
• W1932456596 sameAs 1932456596 @default.
• W1932456596 citedByCount "10" @default.
• W1932456596 countsByYear W19324565962015 @default.
• W1932456596 countsByYear W19324565962017 @default.
• W1932456596 countsByYear W19324565962019 @default.
• W1932456596 countsByYear W19324565962020 @default.
• W1932456596 countsByYear W19324565962021 @default.
• W1932456596 countsByYear W19324565962022 @default.
• W1932456596 countsByYear W19324565962023 @default.
• W1932456596 crossrefType "journal-article" @default.
• W1932456596 hasAuthorship W1932456596A5027209735 @default.
• W1932456596 hasAuthorship W1932456596A5033244305 @default.
• W1932456596 hasAuthorship W1932456596A5074511442 @default.
• W1932456596 hasBestOaLocation W19324565961 @default.
• W1932456596 hasConcept C104317684 @default.
• W1932456596 hasConcept C106436119 @default.
• W1932456596 hasConcept C111337013 @default.
• W1932456596 hasConcept C111919701 @default.
• W1932456596 hasConcept C115901376 @default.
• W1932456596 hasConcept C121332964 @default.
• W1932456596 hasConcept C124101348 @default.
• W1932456596 hasConcept C127413603 @default.
• W1932456596 hasConcept C157764524 @default.
• W1932456596 hasConcept C18231593 @default.
• W1932456596 hasConcept C185544564 @default.
• W1932456596 hasConcept C185592680 @default.
• W1932456596 hasConcept C198531522 @default.
• W1932456596 hasConcept C200601418 @default.
• W1932456596 hasConcept C21547014 @default.
• W1932456596 hasConcept C2778618615 @default.
• W1932456596 hasConcept C2779254040 @default.
• W1932456596 hasConcept C2994296024 @default.
• W1932456596 hasConcept C30481170 @default.
• W1932456596 hasConcept C41008148 @default.
• W1932456596 hasConcept C43617362 @default.
• W1932456596 hasConcept C54355233 @default.
• W1932456596 hasConcept C555944384 @default.
• W1932456596 hasConcept C78519656 @default.
• W1932456596 hasConcept C85135244 @default.
• W1932456596 hasConcept C86803240 @default.
• W1932456596 hasConceptScore W1932456596C104317684 @default.
• W1932456596 hasConceptScore W1932456596C106436119 @default.
• W1932456596 hasConceptScore W1932456596C111337013 @default.
• W1932456596 hasConceptScore W1932456596C111919701 @default.
• W1932456596 hasConceptScore W1932456596C115901376 @default.
• W1932456596 hasConceptScore W1932456596C121332964 @default.
• W1932456596 hasConceptScore W1932456596C124101348 @default.
• W1932456596 hasConceptScore W1932456596C127413603 @default.
• W1932456596 hasConceptScore W1932456596C157764524 @default.
• W1932456596 hasConceptScore W1932456596C18231593 @default.
• W1932456596 hasConceptScore W1932456596C185544564 @default.
• W1932456596 hasConceptScore W1932456596C185592680 @default.
• W1932456596 hasConceptScore W1932456596C198531522 @default.
• W1932456596 hasConceptScore W1932456596C200601418 @default.
• W1932456596 hasConceptScore W1932456596C21547014 @default.
• W1932456596 hasConceptScore W1932456596C2778618615 @default.
• W1932456596 hasConceptScore W1932456596C2779254040 @default.
• W1932456596 hasConceptScore W1932456596C2994296024 @default.
• W1932456596 hasConceptScore W1932456596C30481170 @default.
• W1932456596 hasConceptScore W1932456596C41008148 @default.
• W1932456596 hasConceptScore W1932456596C43617362 @default.
• W1932456596 hasConceptScore W1932456596C54355233 @default.
• W1932456596 hasConceptScore W1932456596C555944384 @default.
• W1932456596 hasConceptScore W1932456596C78519656 @default.

• next