FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1932543353> ?p ?o ?g. }

• W1932543353 endingPage "939" @default.
• W1932543353 startingPage "929" @default.
• W1932543353 abstract "Summary Plasmodium salivary gland sporozoites upregulate expression of a unique subset of genes, collectively called the UIS (upregulated in infectious sporozoites). Many UIS were shown to be essential for early liver stage development, although little is known about their regulation. We previously identified a conserved sporozoite‐specific protein, SAP1, which has an essential role in Plasmodium liver infection. Targeted deletion of SAP1 in Plasmodium yoelii caused the depletion of a number of selectively tested UIS transcripts in sporozoites, resulting in a complete early liver stage arrest. Here, we use a global gene expression survey to more comprehensively identify transcripts that are affected by SAP1 deletion. We find an effect upon both the transcript abundance of UIS genes, as well as of select genes previously not grouped as UIS . Importantly, we show that the lack of SAP1 causes the specific degradation of these transcripts. Collectively, our data suggest that SAP1 is involved in a selective post‐transcriptional mechanism to regulate the abundance of transcripts critical to the infectivity of sporozoites. Although Pysap1 ‐ sporozoites are depleted of many of these important transcripts, they confer long‐lasting sterile protection against wild‐type sporozoite challenge in mice. SAP1 is therefore an appealing candidate locus for attenuation of Plasmodium falciparum ." @default.
• W1932543353 created "2016-06-24" @default.
• W1932543353 creator A5009057593 @default.
• W1932543353 creator A5010911294 @default.
• W1932543353 creator A5014639053 @default.
• W1932543353 creator A5060247652 @default.
• W1932543353 creator A5061633699 @default.
• W1932543353 date "2010-12-22" @default.
• W1932543353 modified "2023-10-16" @default.
• W1932543353 title "SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages" @default.
• W1932543353 cites W1576233700 @default.
• W1932543353 cites W1931794862 @default.
• W1932543353 cites W1996871916 @default.
• W1932543353 cites W2002928823 @default.
• W1932543353 cites W2009635288 @default.
• W1932543353 cites W2010785923 @default.
• W1932543353 cites W2019809965 @default.
• W1932543353 cites W2023160008 @default.
• W1932543353 cites W2027536884 @default.
• W1932543353 cites W2038121339 @default.
• W1932543353 cites W2038841385 @default.
• W1932543353 cites W2039481952 @default.
• W1932543353 cites W2044821390 @default.
• W1932543353 cites W2057434233 @default.
• W1932543353 cites W2060564531 @default.
• W1932543353 cites W2061276931 @default.
• W1932543353 cites W2064864983 @default.
• W1932543353 cites W2070136956 @default.
• W1932543353 cites W2072269419 @default.
• W1932543353 cites W2076495609 @default.
• W1932543353 cites W2083280521 @default.
• W1932543353 cites W2088366327 @default.
• W1932543353 cites W2090169676 @default.
• W1932543353 cites W2097370940 @default.
• W1932543353 cites W2109122531 @default.
• W1932543353 cites W2113206880 @default.
• W1932543353 cites W2116592258 @default.
• W1932543353 cites W2122598723 @default.
• W1932543353 cites W2129895984 @default.
• W1932543353 cites W2131197002 @default.
• W1932543353 cites W2138623091 @default.
• W1932543353 cites W2152770371 @default.
• W1932543353 cites W2161746138 @default.
• W1932543353 cites W2162355257 @default.
• W1932543353 cites W2164312318 @default.
• W1932543353 cites W2170017808 @default.
• W1932543353 cites W2172215633 @default.
• W1932543353 cites W2327705511 @default.
• W1932543353 doi "https://doi.org/10.1111/j.1365-2958.2010.07497.x" @default.
• W1932543353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21299648" @default.
• W1932543353 hasPublicationYear "2010" @default.
• W1932543353 type Work @default.
• W1932543353 sameAs 1932543353 @default.
• W1932543353 citedByCount "46" @default.
• W1932543353 countsByYear W19325433532012 @default.
• W1932543353 countsByYear W19325433532013 @default.
• W1932543353 countsByYear W19325433532014 @default.
• W1932543353 countsByYear W19325433532015 @default.
• W1932543353 countsByYear W19325433532016 @default.
• W1932543353 countsByYear W19325433532017 @default.
• W1932543353 countsByYear W19325433532018 @default.
• W1932543353 countsByYear W19325433532019 @default.
• W1932543353 countsByYear W19325433532020 @default.
• W1932543353 countsByYear W19325433532021 @default.
• W1932543353 countsByYear W19325433532022 @default.
• W1932543353 countsByYear W19325433532023 @default.
• W1932543353 crossrefType "journal-article" @default.
• W1932543353 hasAuthorship W1932543353A5009057593 @default.
• W1932543353 hasAuthorship W1932543353A5010911294 @default.
• W1932543353 hasAuthorship W1932543353A5014639053 @default.
• W1932543353 hasAuthorship W1932543353A5060247652 @default.
• W1932543353 hasAuthorship W1932543353A5061633699 @default.
• W1932543353 hasConcept C104317684 @default.
• W1932543353 hasConcept C106358424 @default.
• W1932543353 hasConcept C127561419 @default.
• W1932543353 hasConcept C150194340 @default.
• W1932543353 hasConcept C203014093 @default.
• W1932543353 hasConcept C2522874641 @default.
• W1932543353 hasConcept C2775867548 @default.
• W1932543353 hasConcept C2776486806 @default.
• W1932543353 hasConcept C2778048844 @default.
• W1932543353 hasConcept C2778371730 @default.
• W1932543353 hasConcept C54355233 @default.
• W1932543353 hasConcept C86803240 @default.
• W1932543353 hasConcept C95444343 @default.
• W1932543353 hasConceptScore W1932543353C104317684 @default.
• W1932543353 hasConceptScore W1932543353C106358424 @default.
• W1932543353 hasConceptScore W1932543353C127561419 @default.
• W1932543353 hasConceptScore W1932543353C150194340 @default.
• W1932543353 hasConceptScore W1932543353C203014093 @default.
• W1932543353 hasConceptScore W1932543353C2522874641 @default.
• W1932543353 hasConceptScore W1932543353C2775867548 @default.
• W1932543353 hasConceptScore W1932543353C2776486806 @default.
• W1932543353 hasConceptScore W1932543353C2778048844 @default.
• W1932543353 hasConceptScore W1932543353C2778371730 @default.
• W1932543353 hasConceptScore W1932543353C54355233 @default.
• W1932543353 hasConceptScore W1932543353C86803240 @default.
• W1932543353 hasConceptScore W1932543353C95444343 @default.

• next