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• W1932550628 endingPage "69" @default.
• W1932550628 startingPage "63" @default.
• W1932550628 abstract "The immunocytological distribution of the proliferating cell nuclear antigen (PCNA), a protein involved in DNA replication, has been examined during the early development of Xenopus laevis. The protein is uniformly detected in nuclei during early stages up to the neurula stage. PCNA is detected by its distinctive cyclical pattern during early development, remaining detectable only during the period of S phase of each cell cycle. Immunological detection of PCNA is therefore a useful and specific non-isotopic marker of S-phase cells in the embryo. PCNA associates with typical karyomeric structures, suggesting that DNA replication starts before the nuclear compartment is entirely formed. At the midblastula transition, a new pattern of PCNA staining becomes apparent. First, a new type of PCNA staining is detected at the nuclear periphery. Second, mitotic clusters with different PCNA distributions suggest that the onset of desynchronization of the cell cycle at this stage is not random." @default.
• W1932550628 created "2016-06-24" @default.
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• W1932550628 date "1992-05-01" @default.
• W1932550628 modified "2023-10-09" @default.
• W1932550628 title "Nuclear distribution of PCNA during embryonic development in <i>Xenopus laevis:</i> a reinvestigation of early cell cycles" @default.
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• W1932550628 doi "https://doi.org/10.1242/jcs.102.1.63" @default.
• W1932550628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1354219" @default.
• W1932550628 hasPublicationYear "1992" @default.
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