FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1932582448> ?p ?o ?g. }

• W1932582448 endingPage "198" @default.
• W1932582448 startingPage "187" @default.
• W1932582448 abstract "A plethora of promising breast cancer-associated autoantigens have been cloned by immunoscreening cDNA expression libraries with breast cancer sera or identified using proteomics, yet no biomarkers, whether individual autoantigens or panels of antigens developed using antibody-based methods have been validated and incorporated to routine oncologic practice for the early diagnosis of breast cancer. Recently, the addition of genomics, proteomics and high throughput technology to traditional immunological techniques has revived the interest in this field, and some of the most promising breast cancer autoantigens are in the process of being validated prospectively in large cohorts of patients with breast cancer. In addition, some of the identified breast cancer-associated autoantigens are recognized by T-cells and may prove to have a role in the treatment of breast cancer in the future. Autoantibodies found in breast cancer patient sera provide important clues about their significance. The discovery of breast cancer-associated antigens has provocative implications beyond the quest for novel diagnostic biomarkers, because autoantibodies target molecules involved in signal transduction, cell cycle regulation, cell proliferation and apoptosis, all of them key processes in carcinogenesis. Molecular components of the DNA double-strand break repair machinery as well as several members of the rapamycin-sensitive pathway elicit an autoantibody response in breast cancer. Data obtained by screening cDNA expression libraries of breast cancer antigens with autoantibodies present in breast cancer sera suggest that autoantibodies in cancer sera may be linked to the process of apoptosis. The studies reviewed here, clearly demonstrate the participation of autoimmunity in breast cancer to an extent previously unsuspected, which may have broad implications for the discovery of molecular targets for drug therapy and cancer biomarkers in general." @default.
• W1932582448 created "2016-06-24" @default.
• W1932582448 creator A5032306807 @default.
• W1932582448 date "2005-12-18" @default.
• W1932582448 modified "2023-09-30" @default.
• W1932582448 title "Autoantibodies in breast cancer sera: candidate biomarkers and reporters of tumorigenesis" @default.
• W1932582448 cites W1501136812 @default.
• W1932582448 cites W1533565768 @default.
• W1932582448 cites W1543340423 @default.
• W1932582448 cites W1544106831 @default.
• W1932582448 cites W1552738427 @default.
• W1932582448 cites W1553480359 @default.
• W1932582448 cites W1553540409 @default.
• W1932582448 cites W1566775766 @default.
• W1932582448 cites W1576215795 @default.
• W1932582448 cites W1590665808 @default.
• W1932582448 cites W1604521649 @default.
• W1932582448 cites W1606480463 @default.
• W1932582448 cites W1608277957 @default.
• W1932582448 cites W1634646020 @default.
• W1932582448 cites W1659681861 @default.
• W1932582448 cites W1766758424 @default.
• W1932582448 cites W1820106848 @default.
• W1932582448 cites W1841461389 @default.
• W1932582448 cites W1905950615 @default.
• W1932582448 cites W1911450008 @default.
• W1932582448 cites W1914550558 @default.
• W1932582448 cites W1939459473 @default.
• W1932582448 cites W1944351535 @default.
• W1932582448 cites W1956237108 @default.
• W1932582448 cites W1965772972 @default.
• W1932582448 cites W1971405891 @default.
• W1932582448 cites W1973069722 @default.
• W1932582448 cites W1977035912 @default.
• W1932582448 cites W1982229435 @default.
• W1932582448 cites W1982545858 @default.
• W1932582448 cites W1988743517 @default.
• W1932582448 cites W1994468555 @default.
• W1932582448 cites W1994702594 @default.
• W1932582448 cites W1998257437 @default.
• W1932582448 cites W2000595178 @default.
• W1932582448 cites W2000916122 @default.
• W1932582448 cites W2002653737 @default.
• W1932582448 cites W2003096758 @default.
• W1932582448 cites W2006148642 @default.
• W1932582448 cites W2007749743 @default.
• W1932582448 cites W2013743651 @default.
• W1932582448 cites W2013993442 @default.
• W1932582448 cites W2016557482 @default.
• W1932582448 cites W2016793236 @default.
• W1932582448 cites W2024479979 @default.
• W1932582448 cites W2024963375 @default.
• W1932582448 cites W2026666255 @default.
• W1932582448 cites W2032232569 @default.
• W1932582448 cites W2036851895 @default.
• W1932582448 cites W2042174530 @default.
• W1932582448 cites W2043013160 @default.
• W1932582448 cites W2044230490 @default.
• W1932582448 cites W2044713924 @default.
• W1932582448 cites W2045357880 @default.
• W1932582448 cites W2047745891 @default.
• W1932582448 cites W2048794678 @default.
• W1932582448 cites W2052473190 @default.
• W1932582448 cites W2052997882 @default.
• W1932582448 cites W2054985048 @default.
• W1932582448 cites W2055365424 @default.
• W1932582448 cites W2056490499 @default.
• W1932582448 cites W2056733153 @default.
• W1932582448 cites W2058688467 @default.
• W1932582448 cites W2059406229 @default.
• W1932582448 cites W2063607410 @default.
• W1932582448 cites W2068359998 @default.
• W1932582448 cites W2072798332 @default.
• W1932582448 cites W2075847417 @default.
• W1932582448 cites W2076017497 @default.
• W1932582448 cites W2078882775 @default.
• W1932582448 cites W2079194996 @default.
• W1932582448 cites W2081070014 @default.
• W1932582448 cites W2081221632 @default.
• W1932582448 cites W2085990761 @default.
• W1932582448 cites W2094014256 @default.
• W1932582448 cites W2094622652 @default.
• W1932582448 cites W2099552271 @default.
• W1932582448 cites W2101082869 @default.
• W1932582448 cites W2103990111 @default.
• W1932582448 cites W2113028890 @default.
• W1932582448 cites W2115808409 @default.
• W1932582448 cites W2119270486 @default.
• W1932582448 cites W2119518409 @default.
• W1932582448 cites W2119908867 @default.
• W1932582448 cites W2121512011 @default.
• W1932582448 cites W2121514893 @default.
• W1932582448 cites W2123377260 @default.
• W1932582448 cites W2130184077 @default.
• W1932582448 cites W2130915789 @default.
• W1932582448 cites W2131251766 @default.
• W1932582448 cites W2133123321 @default.
• W1932582448 cites W2135178321 @default.

• next