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- W1932604562 abstract "Life on earth depends on dynamic chemical transformations that enable cellular functions, including electron transfer reactions, as well as synthesis and degradation of biomolecules. Biochemical reactions are coordinated in metabolic pathways that interact in a complex way to allow adequate regulation. Biotechnology, food, biofuels, agricultural and pharmaceutical industries are highly interested in metabolic engineering as an enabling technology of synthetic biology to exploit cells for the controlled production of metabolites of interest. These approaches have only recently been extended to plants due to their greater metabolic complexity (such as primary and secondary metabolism) and highly compartmentalized cellular structures and functions (including plant-specific organelles) compared with bacteria and other microorganisms. Technological advances in analytical instrumentation in combination with advances in data analysis and modeling have opened up new approaches to engineer plant metabolic pathways, and allow the impact of modifications to be predicted more accurately. In this article, we review challenges in the integration and analysis of large-scale metabolic data, present an overview of current bioinformatics methods for the modeling and visualization of metabolic networks, and discuss approaches for interfacing bioinformatics approaches with metabolic models of cellular processes and flux distributions in order to predict phenotypes derived from specific genetic modifications, or subjected to different environmental conditions." @default.
- W1932604562 created "2016-06-24" @default.
- W1932604562 creator A5003441276 @default.
- W1932604562 creator A5033904916 @default.
- W1932604562 creator A5035416919 @default.
- W1932604562 creator A5040908598 @default.
- W1932604562 creator A5062149146 @default.
- W1932604562 date "2015-10-21" @default.
- W1932604562 modified "2023-10-17" @default.
- W1932604562 title "Metabolomics, Standards, and Metabolic Modeling for Synthetic Biology in Plants" @default.
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