Matches in SemOpenAlex for { <https://semopenalex.org/work/W1932607286> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1932607286 endingPage "2097" @default.
- W1932607286 startingPage "2090" @default.
- W1932607286 abstract "Neutralizing antibodies and cellular immune response both play essential roles in the clearance of Hepatitis C virus (HCV) infection. The envelope glycoprotein E2 is a major target for producing neutralizing antibodies against HCV. Here, we constructed a recombinant plasmid, termed pcDNA3.1-E2-Fc, to express HCV E2 with an immunoglobulin Fc fusion tag (E2-Fc). Importantly, we found that the titers of E2-specific IgG from mice immunized with pcDNA3.1-E2-Fc were significantly higher than that from mice immunized with pcDNA3.1-E2. Moreover, pcDNA3.1-E2-Fc immunization could boost E2-specific lymphocyte proliferation and enhance the secretion of IFN-γ by lymphocytes upon in vitro stimulation with soluble E2 compared to pcDNA3.1-E2 immunization. Neutralization assays showed that serum from pcDNA3.1-E2-Fc immunized mice exhibited more effective neutralizing capacity of HCVpp entry into Huh-7 cells compared with that from pcDNA3.1-E2 immunized mice, although both of the sera could inhibit the virus entry. Taken together, our results imply that pcDNA3.1-E2-Fc immunization could enhance E2-specific humoral and cellular immune response in mice and thus provide a promising candidate for the development of an HCV vaccine." @default.
- W1932607286 created "2016-06-24" @default.
- W1932607286 creator A5029228548 @default.
- W1932607286 creator A5047713923 @default.
- W1932607286 creator A5054454797 @default.
- W1932607286 creator A5055950313 @default.
- W1932607286 creator A5066833546 @default.
- W1932607286 creator A5066887020 @default.
- W1932607286 creator A5067319190 @default.
- W1932607286 creator A5078840950 @default.
- W1932607286 date "2015-06-12" @default.
- W1932607286 modified "2023-10-08" @default.
- W1932607286 title "Enhancement of immune response to a hepatitis C virus E2 DNA vaccine by an immunoglobulin Fc fusion tag" @default.
- W1932607286 cites W1505139021 @default.
- W1932607286 cites W1970998040 @default.
- W1932607286 cites W1992123743 @default.
- W1932607286 cites W1993259796 @default.
- W1932607286 cites W1997677874 @default.
- W1932607286 cites W2003499726 @default.
- W1932607286 cites W2004084345 @default.
- W1932607286 cites W2020004919 @default.
- W1932607286 cites W2021900004 @default.
- W1932607286 cites W2023064711 @default.
- W1932607286 cites W2027555790 @default.
- W1932607286 cites W2028161109 @default.
- W1932607286 cites W2035179120 @default.
- W1932607286 cites W2036836249 @default.
- W1932607286 cites W2042282764 @default.
- W1932607286 cites W2053817738 @default.
- W1932607286 cites W2056877436 @default.
- W1932607286 cites W2075600964 @default.
- W1932607286 cites W2092161253 @default.
- W1932607286 cites W2099046838 @default.
- W1932607286 cites W2110223801 @default.
- W1932607286 cites W2113864802 @default.
- W1932607286 cites W2118407630 @default.
- W1932607286 cites W2127444976 @default.
- W1932607286 cites W2149751691 @default.
- W1932607286 cites W2161906796 @default.
- W1932607286 doi "https://doi.org/10.1002/jmv.24277" @default.
- W1932607286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26010499" @default.
- W1932607286 hasPublicationYear "2015" @default.
- W1932607286 type Work @default.
- W1932607286 sameAs 1932607286 @default.
- W1932607286 citedByCount "3" @default.
- W1932607286 countsByYear W19326072862015 @default.
- W1932607286 countsByYear W19326072862019 @default.
- W1932607286 countsByYear W19326072862021 @default.
- W1932607286 crossrefType "journal-article" @default.
- W1932607286 hasAuthorship W1932607286A5029228548 @default.
- W1932607286 hasAuthorship W1932607286A5047713923 @default.
- W1932607286 hasAuthorship W1932607286A5054454797 @default.
- W1932607286 hasAuthorship W1932607286A5055950313 @default.
- W1932607286 hasAuthorship W1932607286A5066833546 @default.
- W1932607286 hasAuthorship W1932607286A5066887020 @default.
- W1932607286 hasAuthorship W1932607286A5067319190 @default.
- W1932607286 hasAuthorship W1932607286A5078840950 @default.
- W1932607286 hasConcept C14086860 @default.
- W1932607286 hasConcept C159047783 @default.
- W1932607286 hasConcept C159654299 @default.
- W1932607286 hasConcept C203014093 @default.
- W1932607286 hasConcept C2522874641 @default.
- W1932607286 hasConcept C2779261636 @default.
- W1932607286 hasConcept C2780801004 @default.
- W1932607286 hasConcept C2780898057 @default.
- W1932607286 hasConcept C86803240 @default.
- W1932607286 hasConcept C8891405 @default.
- W1932607286 hasConceptScore W1932607286C14086860 @default.
- W1932607286 hasConceptScore W1932607286C159047783 @default.
- W1932607286 hasConceptScore W1932607286C159654299 @default.
- W1932607286 hasConceptScore W1932607286C203014093 @default.
- W1932607286 hasConceptScore W1932607286C2522874641 @default.
- W1932607286 hasConceptScore W1932607286C2779261636 @default.
- W1932607286 hasConceptScore W1932607286C2780801004 @default.
- W1932607286 hasConceptScore W1932607286C2780898057 @default.
- W1932607286 hasConceptScore W1932607286C86803240 @default.
- W1932607286 hasConceptScore W1932607286C8891405 @default.
- W1932607286 hasFunder F4320321001 @default.
- W1932607286 hasIssue "12" @default.
- W1932607286 hasLocation W19326072861 @default.
- W1932607286 hasLocation W19326072862 @default.
- W1932607286 hasOpenAccess W1932607286 @default.
- W1932607286 hasPrimaryLocation W19326072861 @default.
- W1932607286 hasRelatedWork W1967083729 @default.
- W1932607286 hasRelatedWork W1972745941 @default.
- W1932607286 hasRelatedWork W1974138678 @default.
- W1932607286 hasRelatedWork W2011115096 @default.
- W1932607286 hasRelatedWork W2043102346 @default.
- W1932607286 hasRelatedWork W2054563937 @default.
- W1932607286 hasRelatedWork W2076366830 @default.
- W1932607286 hasRelatedWork W2078097518 @default.
- W1932607286 hasRelatedWork W2127776899 @default.
- W1932607286 hasRelatedWork W4321242708 @default.
- W1932607286 hasVolume "87" @default.
- W1932607286 isParatext "false" @default.
- W1932607286 isRetracted "false" @default.
- W1932607286 magId "1932607286" @default.
- W1932607286 workType "article" @default.