Matches in SemOpenAlex for { <https://semopenalex.org/work/W1932660839> ?p ?o ?g. }
- W1932660839 endingPage "383" @default.
- W1932660839 startingPage "378" @default.
- W1932660839 abstract "The serum protein lipopolysaccharide (LPS)-binding protein (LBP) seems to play an important role in regulating host responses to LPS. Complexes of LPS and LBP form in serum and stimulate monocytes, macrophages, or polymorphonuclear leukocytes after binding to CD14. Previous reports have described the structure and properties of LBP from human and rabbit sera. Since mice are used in some experimental models of endotoxemia or gram-negative bacterial infections, information is needed about the properties of murine LBP. Murine LBP was purified by ion-exchange chromatography and high-pressure liquid chromatography; its NH2-terminal sequence (TNPGLVTRIT) was very similar to those of human and rabbit LBPs (80 to 90% amino acid identity). Murine LBP resembled LBPs from other species in that it promoted the binding of LPS to monocytes and enhanced the sensitivity of monocytes to LPS at least 100-fold. Mouse LBP, like rabbit and human LBPs, was found to be an acute-phase protein. Further in vivo studies with mice and anti-CD14 or anti-LBP reagents should help determine the role of LBP in response to LPS challenges." @default.
- W1932660839 created "2016-06-24" @default.
- W1932660839 creator A5007254781 @default.
- W1932660839 creator A5024621955 @default.
- W1932660839 creator A5037380925 @default.
- W1932660839 creator A5060217430 @default.
- W1932660839 creator A5065320926 @default.
- W1932660839 creator A5070147660 @default.
- W1932660839 creator A5072001348 @default.
- W1932660839 creator A5078314686 @default.
- W1932660839 date "1993-02-01" @default.
- W1932660839 modified "2023-09-25" @default.
- W1932660839 title "Purification and characterization of murine lipopolysaccharide-binding protein" @default.
- W1932660839 cites W1568761178 @default.
- W1932660839 cites W1622047218 @default.
- W1932660839 cites W1962480635 @default.
- W1932660839 cites W1969411212 @default.
- W1932660839 cites W2017347652 @default.
- W1932660839 cites W2029157767 @default.
- W1932660839 cites W2046847142 @default.
- W1932660839 cites W2064626913 @default.
- W1932660839 cites W2071670327 @default.
- W1932660839 cites W2083077668 @default.
- W1932660839 cites W2087934471 @default.
- W1932660839 cites W2100837269 @default.
- W1932660839 cites W2101108802 @default.
- W1932660839 cites W2123987062 @default.
- W1932660839 cites W2130725606 @default.
- W1932660839 cites W2131115069 @default.
- W1932660839 cites W2404371759 @default.
- W1932660839 doi "https://doi.org/10.1128/iai.61.2.378-383.1993" @default.
- W1932660839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/302740" @default.
- W1932660839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7678583" @default.
- W1932660839 hasPublicationYear "1993" @default.
- W1932660839 type Work @default.
- W1932660839 sameAs 1932660839 @default.
- W1932660839 citedByCount "39" @default.
- W1932660839 countsByYear W19326608392013 @default.
- W1932660839 countsByYear W19326608392017 @default.
- W1932660839 crossrefType "journal-article" @default.
- W1932660839 hasAuthorship W1932660839A5007254781 @default.
- W1932660839 hasAuthorship W1932660839A5024621955 @default.
- W1932660839 hasAuthorship W1932660839A5037380925 @default.
- W1932660839 hasAuthorship W1932660839A5060217430 @default.
- W1932660839 hasAuthorship W1932660839A5065320926 @default.
- W1932660839 hasAuthorship W1932660839A5070147660 @default.
- W1932660839 hasAuthorship W1932660839A5072001348 @default.
- W1932660839 hasAuthorship W1932660839A5078314686 @default.
- W1932660839 hasBestOaLocation W19326608391 @default.
- W1932660839 hasConcept C104317684 @default.
- W1932660839 hasConcept C150903083 @default.
- W1932660839 hasConcept C153911025 @default.
- W1932660839 hasConcept C167625842 @default.
- W1932660839 hasConcept C202751555 @default.
- W1932660839 hasConcept C203014093 @default.
- W1932660839 hasConcept C207001950 @default.
- W1932660839 hasConcept C2776822972 @default.
- W1932660839 hasConcept C2776914184 @default.
- W1932660839 hasConcept C2778513237 @default.
- W1932660839 hasConcept C2778754761 @default.
- W1932660839 hasConcept C55493867 @default.
- W1932660839 hasConcept C57194454 @default.
- W1932660839 hasConcept C86803240 @default.
- W1932660839 hasConcept C8891405 @default.
- W1932660839 hasConceptScore W1932660839C104317684 @default.
- W1932660839 hasConceptScore W1932660839C150903083 @default.
- W1932660839 hasConceptScore W1932660839C153911025 @default.
- W1932660839 hasConceptScore W1932660839C167625842 @default.
- W1932660839 hasConceptScore W1932660839C202751555 @default.
- W1932660839 hasConceptScore W1932660839C203014093 @default.
- W1932660839 hasConceptScore W1932660839C207001950 @default.
- W1932660839 hasConceptScore W1932660839C2776822972 @default.
- W1932660839 hasConceptScore W1932660839C2776914184 @default.
- W1932660839 hasConceptScore W1932660839C2778513237 @default.
- W1932660839 hasConceptScore W1932660839C2778754761 @default.
- W1932660839 hasConceptScore W1932660839C55493867 @default.
- W1932660839 hasConceptScore W1932660839C57194454 @default.
- W1932660839 hasConceptScore W1932660839C86803240 @default.
- W1932660839 hasConceptScore W1932660839C8891405 @default.
- W1932660839 hasIssue "2" @default.
- W1932660839 hasLocation W19326608391 @default.
- W1932660839 hasLocation W19326608392 @default.
- W1932660839 hasLocation W19326608393 @default.
- W1932660839 hasOpenAccess W1932660839 @default.
- W1932660839 hasPrimaryLocation W19326608391 @default.
- W1932660839 hasRelatedWork W1932660839 @default.
- W1932660839 hasRelatedWork W1982844650 @default.
- W1932660839 hasRelatedWork W1996009196 @default.
- W1932660839 hasRelatedWork W2023484935 @default.
- W1932660839 hasRelatedWork W2040642611 @default.
- W1932660839 hasRelatedWork W2050611363 @default.
- W1932660839 hasRelatedWork W2095044753 @default.
- W1932660839 hasRelatedWork W2106161615 @default.
- W1932660839 hasRelatedWork W2166108529 @default.
- W1932660839 hasRelatedWork W2916252706 @default.
- W1932660839 hasVolume "61" @default.
- W1932660839 isParatext "false" @default.
- W1932660839 isRetracted "false" @default.