FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1932788968> ?p ?o ?g. }

• W1932788968 endingPage "119" @default.
• W1932788968 startingPage "111" @default.
• W1932788968 abstract "MicroRNAs are endogenously expressed small noncoding RNAs that regulate gene expression. Laminar blood flow induces atheroprotective gene expression in endothelial cells (ECs) in part by upregulating the transcription factor KLF2. Here, we identified KLF2- and flow-responsive miRs that affect gene expression in ECs. Bioinformatic assessment of mRNA expression patterns identified the miR-30-5p seed sequence to be highly enriched in mRNAs that are downregulated by KLF2. Indeed, KLF2 overexpression and shear stress stimulation in vitro and in vivo increased the expression of miR-30-5p family members. Furthermore, we identified angiopoietin 2 (Ang2) as a target of miR-30. MiR-30 overexpression reduces Ang2 levels, whereas miR-30 inhibition by LNA-antimiRs induces Ang2 expression. Consistently, miR-30 reduced basal and TNF-α-induced expression of the inflammatory cell–cell adhesion molecules E-selectin, ICAM1 and VCAM1, which was rescued by stimulation with exogenous Ang2. In summary, KLF2 and shear stress increase the expression of the miR-30-5p family which acts in an anti-inflammatory manner in ECs by impairing the expression of Ang2 and inflammatory cell–cell adhesion molecules. The upregulation of miR-30-5p family members may contribute to the atheroprotective effects of shear stress." @default.
• W1932788968 created "2016-06-24" @default.
• W1932788968 creator A5005077808 @default.
• W1932788968 creator A5016611690 @default.
• W1932788968 creator A5022050150 @default.
• W1932788968 creator A5022309505 @default.
• W1932788968 creator A5031110277 @default.
• W1932788968 creator A5033335642 @default.
• W1932788968 creator A5036005396 @default.
• W1932788968 creator A5036067969 @default.
• W1932788968 creator A5036354220 @default.
• W1932788968 creator A5041000300 @default.
• W1932788968 creator A5056998132 @default.
• W1932788968 creator A5069528663 @default.
• W1932788968 creator A5075728423 @default.
• W1932788968 creator A5086722857 @default.
• W1932788968 creator A5090073719 @default.
• W1932788968 date "2015-11-01" @default.
• W1932788968 modified "2023-10-14" @default.
• W1932788968 title "MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2" @default.
• W1932788968 cites W1963906441 @default.
• W1932788968 cites W1965222513 @default.
• W1932788968 cites W1968035201 @default.
• W1932788968 cites W1968125429 @default.
• W1932788968 cites W1969294374 @default.
• W1932788968 cites W1982954728 @default.
• W1932788968 cites W1983266682 @default.
• W1932788968 cites W1987943440 @default.
• W1932788968 cites W1988878654 @default.
• W1932788968 cites W1989368535 @default.
• W1932788968 cites W2008961036 @default.
• W1932788968 cites W2019459677 @default.
• W1932788968 cites W2024861740 @default.
• W1932788968 cites W2035809865 @default.
• W1932788968 cites W2036090950 @default.
• W1932788968 cites W2040919803 @default.
• W1932788968 cites W2044586762 @default.
• W1932788968 cites W2050879491 @default.
• W1932788968 cites W2071925802 @default.
• W1932788968 cites W2074979486 @default.
• W1932788968 cites W2076136347 @default.
• W1932788968 cites W2079245209 @default.
• W1932788968 cites W2085038746 @default.
• W1932788968 cites W2088797440 @default.
• W1932788968 cites W2091959384 @default.
• W1932788968 cites W2099196609 @default.
• W1932788968 cites W2100031693 @default.
• W1932788968 cites W2100454247 @default.
• W1932788968 cites W2105272944 @default.
• W1932788968 cites W2107782164 @default.
• W1932788968 cites W2115206563 @default.
• W1932788968 cites W2126612686 @default.
• W1932788968 cites W2130154562 @default.
• W1932788968 cites W2130410032 @default.
• W1932788968 cites W2139204931 @default.
• W1932788968 cites W2143895919 @default.
• W1932788968 cites W2145642719 @default.
• W1932788968 cites W2147107152 @default.
• W1932788968 cites W2157626278 @default.
• W1932788968 cites W2157985193 @default.
• W1932788968 cites W2161844910 @default.
• W1932788968 cites W2162789670 @default.
• W1932788968 cites W2164122959 @default.
• W1932788968 cites W2166972310 @default.
• W1932788968 cites W4231032814 @default.
• W1932788968 doi "https://doi.org/10.1016/j.yjmcc.2015.10.009" @default.
• W1932788968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26456066" @default.
• W1932788968 hasPublicationYear "2015" @default.
• W1932788968 type Work @default.
• W1932788968 sameAs 1932788968 @default.
• W1932788968 citedByCount "47" @default.
• W1932788968 countsByYear W19327889682016 @default.
• W1932788968 countsByYear W19327889682017 @default.
• W1932788968 countsByYear W19327889682018 @default.
• W1932788968 countsByYear W19327889682019 @default.
• W1932788968 countsByYear W19327889682020 @default.
• W1932788968 countsByYear W19327889682021 @default.
• W1932788968 countsByYear W19327889682022 @default.
• W1932788968 countsByYear W19327889682023 @default.
• W1932788968 crossrefType "journal-article" @default.
• W1932788968 hasAuthorship W1932788968A5005077808 @default.
• W1932788968 hasAuthorship W1932788968A5016611690 @default.
• W1932788968 hasAuthorship W1932788968A5022050150 @default.
• W1932788968 hasAuthorship W1932788968A5022309505 @default.
• W1932788968 hasAuthorship W1932788968A5031110277 @default.
• W1932788968 hasAuthorship W1932788968A5033335642 @default.
• W1932788968 hasAuthorship W1932788968A5036005396 @default.
• W1932788968 hasAuthorship W1932788968A5036067969 @default.
• W1932788968 hasAuthorship W1932788968A5036354220 @default.
• W1932788968 hasAuthorship W1932788968A5041000300 @default.
• W1932788968 hasAuthorship W1932788968A5056998132 @default.
• W1932788968 hasAuthorship W1932788968A5069528663 @default.
• W1932788968 hasAuthorship W1932788968A5075728423 @default.
• W1932788968 hasAuthorship W1932788968A5086722857 @default.
• W1932788968 hasAuthorship W1932788968A5090073719 @default.
• W1932788968 hasConcept C104317684 @default.
• W1932788968 hasConcept C121332964 @default.
• W1932788968 hasConcept C145059251 @default.

• next