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- W1933050657 endingPage "797" @default.
- W1933050657 startingPage "773" @default.
- W1933050657 abstract "Thermogenesis, the production of heat energy, is an essential component of the homeostatic repertoire to maintain body temperature in mammals and birds during the challenge of low environmental temperature and plays a key role in elevating body temperature during the febrile response to infection. The primary sources of neurally regulated metabolic heat production are mitochondrial oxidation in brown adipose tissue, increases in heart rate and shivering in skeletal muscle. Thermogenesis is regulated in each of these tissues by parallel networks in the central nervous system, which respond to feedforward afferent signals from cutaneous and core body thermoreceptors and to feedback signals from brain thermosensitive neurons to activate the appropriate sympathetic and somatic efferents. This review summarizes the research leading to a model of the feedforward reflex pathway through which environmental cold stimulates thermogenesis and discusses the influence on this thermoregulatory network of the pyrogenic mediator, prostaglandin E 2 , to increase body temperature. The cold thermal afferent circuit from cutaneous thermal receptors ascends via second‐order thermosensory neurons in the dorsal horn of the spinal cord to activate neurons in the lateral parabrachial nucleus, which drive GABAergic interneurons in the preoptic area to inhibit warm‐sensitive, inhibitory output neurons of the preoptic area. The resulting disinhibition of thermogenesis‐promoting neurons in the dorsomedial hypothalamus and possibly of sympathetic and somatic premotor neurons in the rostral ventromedial medulla, including the raphe pallidus, activates excitatory inputs to spinal sympathetic and somatic motor circuits to drive thermogenesis." @default.
- W1933050657 created "2016-06-24" @default.
- W1933050657 creator A5016084389 @default.
- W1933050657 creator A5068741363 @default.
- W1933050657 creator A5078989242 @default.
- W1933050657 date "2008-06-28" @default.
- W1933050657 modified "2023-10-15" @default.
- W1933050657 title "Central control of thermogenesis in mammals" @default.
- W1933050657 cites W1484414557 @default.
- W1933050657 cites W1495726008 @default.
- W1933050657 cites W1511198581 @default.
- W1933050657 cites W157111344 @default.
- W1933050657 cites W1599289141 @default.
- W1933050657 cites W1647648618 @default.
- W1933050657 cites W1652979112 @default.
- W1933050657 cites W1782643473 @default.
- W1933050657 cites W1845449766 @default.
- W1933050657 cites W1914551835 @default.
- W1933050657 cites W1939684121 @default.
- W1933050657 cites W1964583098 @default.
- W1933050657 cites W1964717842 @default.
- W1933050657 cites W1965509871 @default.
- W1933050657 cites W1967450028 @default.
- W1933050657 cites W1968311327 @default.
- W1933050657 cites W1969002716 @default.
- W1933050657 cites W1970677487 @default.
- W1933050657 cites W1972504341 @default.
- W1933050657 cites W1973328205 @default.
- W1933050657 cites W1975332997 @default.
- W1933050657 cites W1979004668 @default.
- W1933050657 cites W1980741065 @default.
- W1933050657 cites W1982828559 @default.
- W1933050657 cites W1985522462 @default.
- W1933050657 cites W1986410493 @default.
- W1933050657 cites W1986878613 @default.
- W1933050657 cites W1988101558 @default.
- W1933050657 cites W1989645590 @default.
- W1933050657 cites W1990442258 @default.
- W1933050657 cites W1990639968 @default.
- W1933050657 cites W1993531577 @default.
- W1933050657 cites W1993958507 @default.
- W1933050657 cites W1994233462 @default.
- W1933050657 cites W1995301708 @default.
- W1933050657 cites W1995330222 @default.
- W1933050657 cites W1997569298 @default.
- W1933050657 cites W1998963802 @default.
- W1933050657 cites W1999388392 @default.
- W1933050657 cites W1999484754 @default.
- W1933050657 cites W2000380515 @default.
- W1933050657 cites W2002255891 @default.
- W1933050657 cites W2002698019 @default.
- W1933050657 cites W2003343375 @default.
- W1933050657 cites W2003380041 @default.
- W1933050657 cites W2006626133 @default.
- W1933050657 cites W2007564878 @default.
- W1933050657 cites W2008626322 @default.
- W1933050657 cites W2009880851 @default.
- W1933050657 cites W2009967312 @default.
- W1933050657 cites W2011557706 @default.
- W1933050657 cites W2012266117 @default.
- W1933050657 cites W2014086904 @default.
- W1933050657 cites W2016412968 @default.
- W1933050657 cites W2017676045 @default.
- W1933050657 cites W2020042358 @default.
- W1933050657 cites W2021006519 @default.
- W1933050657 cites W2021705483 @default.
- W1933050657 cites W2022711144 @default.
- W1933050657 cites W2024756139 @default.
- W1933050657 cites W2024928397 @default.
- W1933050657 cites W2029009093 @default.
- W1933050657 cites W2029048820 @default.
- W1933050657 cites W2029073828 @default.
- W1933050657 cites W2029909904 @default.
- W1933050657 cites W2030457497 @default.
- W1933050657 cites W2032890357 @default.
- W1933050657 cites W2034458389 @default.
- W1933050657 cites W2034998797 @default.
- W1933050657 cites W2035257142 @default.
- W1933050657 cites W2035946729 @default.
- W1933050657 cites W2036438525 @default.
- W1933050657 cites W2037494787 @default.
- W1933050657 cites W2039016375 @default.
- W1933050657 cites W2039605663 @default.
- W1933050657 cites W2041632921 @default.
- W1933050657 cites W2042295188 @default.
- W1933050657 cites W2043296272 @default.
- W1933050657 cites W2043328385 @default.
- W1933050657 cites W2045812316 @default.
- W1933050657 cites W2046270276 @default.
- W1933050657 cites W2047028684 @default.
- W1933050657 cites W2049673881 @default.
- W1933050657 cites W2049802099 @default.
- W1933050657 cites W2050730203 @default.
- W1933050657 cites W2050781058 @default.
- W1933050657 cites W2055135519 @default.
- W1933050657 cites W2057102790 @default.
- W1933050657 cites W2059732630 @default.
- W1933050657 cites W2059854700 @default.