FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1933112823> ?p ?o ?g. }

• W1933112823 endingPage "146" @default.
• W1933112823 startingPage "139" @default.
• W1933112823 abstract "Background & AimsPatients with autoimmune hepatitis (AIH) can present with symptoms ranging from those that are insidious and nonspecific to acute hepatitis with jaundice. However, some patients have no symptoms at diagnosis and are identified incidentally. We investigated disease progression and outcomes of these 2 groups of patients.MethodsWe performed a retrospective study to compare clinical, immunologic, and histologic features and outcomes of patients with asymptomatic vs symptomatic AIH. We analyzed data collected from 305 patients (90 asymptomatic and 215 with symptoms), diagnosed with AIH from 1994 and 2013, at the Center for the Study and Treatment of the Autoimmune Diseases of the Liver and Biliary System in Bologna, Italy.ResultsAt diagnosis, patients with asymptomatic AIH had significantly lower mean levels of alanine aminotransferase (7.0- ± 8.0-fold the upper limit of normal) than patients with symptomatic disease (23.0- ± 18.0-fold the upper limit of normal; P < .001), and lower mean levels of bilirubin (1.4 ± 1.4 mg/dL vs 8.6 ± 10.4 mg/dL; P < .001). Asymptomatic patients also had significantly lower histologic grades (7.0 ± 2.5) than symptomatic patients (9.0 ± 2.9; P < .001). However, larger proportions of asymptomatic patients had anti–liver/kidney microsomal antibodies type 1 (26.8% vs 13.1%; P < .006), and associated autoimmune thyroid (26.7% vs 12.6%; P = .003) or skin (8.9% vs 2.3%; P = .010) disorders. Age at onset, sex, response to therapy, disease progression, genetic factors, and other autoantibody markers did not differ between patients with asymptomatic vs symptomatic disease.ConclusionsPatients with asymptomatic vs symptomatic AIH have similar courses of disease progression and responses to immunosuppressive agents, and therefore should receive the same treatment. Patients affected by thyroid or dermatologic autoimmune disorders are at increased risk of developing subclinical liver disease, and should be assessed routinely for AIH. Patients with autoimmune hepatitis (AIH) can present with symptoms ranging from those that are insidious and nonspecific to acute hepatitis with jaundice. However, some patients have no symptoms at diagnosis and are identified incidentally. We investigated disease progression and outcomes of these 2 groups of patients. We performed a retrospective study to compare clinical, immunologic, and histologic features and outcomes of patients with asymptomatic vs symptomatic AIH. We analyzed data collected from 305 patients (90 asymptomatic and 215 with symptoms), diagnosed with AIH from 1994 and 2013, at the Center for the Study and Treatment of the Autoimmune Diseases of the Liver and Biliary System in Bologna, Italy. At diagnosis, patients with asymptomatic AIH had significantly lower mean levels of alanine aminotransferase (7.0- ± 8.0-fold the upper limit of normal) than patients with symptomatic disease (23.0- ± 18.0-fold the upper limit of normal; P < .001), and lower mean levels of bilirubin (1.4 ± 1.4 mg/dL vs 8.6 ± 10.4 mg/dL; P < .001). Asymptomatic patients also had significantly lower histologic grades (7.0 ± 2.5) than symptomatic patients (9.0 ± 2.9; P < .001). However, larger proportions of asymptomatic patients had anti–liver/kidney microsomal antibodies type 1 (26.8% vs 13.1%; P < .006), and associated autoimmune thyroid (26.7% vs 12.6%; P = .003) or skin (8.9% vs 2.3%; P = .010) disorders. Age at onset, sex, response to therapy, disease progression, genetic factors, and other autoantibody markers did not differ between patients with asymptomatic vs symptomatic disease. Patients with asymptomatic vs symptomatic AIH have similar courses of disease progression and responses to immunosuppressive agents, and therefore should receive the same treatment. Patients affected by thyroid or dermatologic autoimmune disorders are at increased risk of developing subclinical liver disease, and should be assessed routinely for AIH." @default.
• W1933112823 created "2016-06-24" @default.
• W1933112823 creator A5007750871 @default.
• W1933112823 creator A5008734609 @default.
• W1933112823 creator A5013599409 @default.
• W1933112823 creator A5034642342 @default.
• W1933112823 creator A5048389435 @default.
• W1933112823 creator A5060856636 @default.
• W1933112823 date "2016-01-01" @default.
• W1933112823 modified "2023-10-18" @default.
• W1933112823 title "Features and Progression of Asymptomatic Autoimmune Hepatitis in Italy" @default.
• W1933112823 cites W1965911418 @default.
• W1933112823 cites W1966632314 @default.
• W1933112823 cites W1968081458 @default.
• W1933112823 cites W1969248928 @default.
• W1933112823 cites W1972897452 @default.
• W1933112823 cites W1973130325 @default.
• W1933112823 cites W1973535263 @default.
• W1933112823 cites W1973987160 @default.
• W1933112823 cites W1976643337 @default.
• W1933112823 cites W1978694591 @default.
• W1933112823 cites W1981900811 @default.
• W1933112823 cites W1984076659 @default.
• W1933112823 cites W1996015553 @default.
• W1933112823 cites W1997647425 @default.
• W1933112823 cites W1999316790 @default.
• W1933112823 cites W2000959749 @default.
• W1933112823 cites W2011976259 @default.
• W1933112823 cites W2017492932 @default.
• W1933112823 cites W2022202791 @default.
• W1933112823 cites W2024887187 @default.
• W1933112823 cites W2026650756 @default.
• W1933112823 cites W2030754839 @default.
• W1933112823 cites W2051777721 @default.
• W1933112823 cites W2055526603 @default.
• W1933112823 cites W2055715897 @default.
• W1933112823 cites W2064788410 @default.
• W1933112823 cites W2074294333 @default.
• W1933112823 cites W2081256992 @default.
• W1933112823 cites W2090185072 @default.
• W1933112823 cites W2093227721 @default.
• W1933112823 cites W2132082241 @default.
• W1933112823 cites W2132205159 @default.
• W1933112823 cites W2140967412 @default.
• W1933112823 cites W2151805825 @default.
• W1933112823 cites W2160126419 @default.
• W1933112823 cites W2163691081 @default.
• W1933112823 cites W2322810712 @default.
• W1933112823 cites W2409739413 @default.
• W1933112823 cites W4231144652 @default.
• W1933112823 doi "https://doi.org/10.1016/j.cgh.2015.07.017" @default.
• W1933112823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26192146" @default.
• W1933112823 hasPublicationYear "2016" @default.
• W1933112823 type Work @default.
• W1933112823 sameAs 1933112823 @default.
• W1933112823 citedByCount "22" @default.
• W1933112823 countsByYear W19331128232016 @default.
• W1933112823 countsByYear W19331128232017 @default.
• W1933112823 countsByYear W19331128232018 @default.
• W1933112823 countsByYear W19331128232019 @default.
• W1933112823 countsByYear W19331128232020 @default.
• W1933112823 countsByYear W19331128232021 @default.
• W1933112823 countsByYear W19331128232022 @default.
• W1933112823 countsByYear W19331128232023 @default.
• W1933112823 crossrefType "journal-article" @default.
• W1933112823 hasAuthorship W1933112823A5007750871 @default.
• W1933112823 hasAuthorship W1933112823A5008734609 @default.
• W1933112823 hasAuthorship W1933112823A5013599409 @default.
• W1933112823 hasAuthorship W1933112823A5034642342 @default.
• W1933112823 hasAuthorship W1933112823A5048389435 @default.
• W1933112823 hasAuthorship W1933112823A5060856636 @default.
• W1933112823 hasConcept C126322002 @default.
• W1933112823 hasConcept C2776029263 @default.
• W1933112823 hasConcept C2777203481 @default.
• W1933112823 hasConcept C2777910003 @default.
• W1933112823 hasConcept C2778456037 @default.
• W1933112823 hasConcept C71924100 @default.
• W1933112823 hasConcept C90924648 @default.
• W1933112823 hasConceptScore W1933112823C126322002 @default.
• W1933112823 hasConceptScore W1933112823C2776029263 @default.
• W1933112823 hasConceptScore W1933112823C2777203481 @default.
• W1933112823 hasConceptScore W1933112823C2777910003 @default.
• W1933112823 hasConceptScore W1933112823C2778456037 @default.
• W1933112823 hasConceptScore W1933112823C71924100 @default.
• W1933112823 hasConceptScore W1933112823C90924648 @default.
• W1933112823 hasIssue "1" @default.
• W1933112823 hasLocation W19331128231 @default.
• W1933112823 hasLocation W19331128232 @default.
• W1933112823 hasOpenAccess W1933112823 @default.
• W1933112823 hasPrimaryLocation W19331128231 @default.
• W1933112823 hasRelatedWork W133341763 @default.
• W1933112823 hasRelatedWork W1970978650 @default.
• W1933112823 hasRelatedWork W1976893941 @default.
• W1933112823 hasRelatedWork W1980853545 @default.
• W1933112823 hasRelatedWork W1982895219 @default.
• W1933112823 hasRelatedWork W2147462014 @default.
• W1933112823 hasRelatedWork W2334527718 @default.
• W1933112823 hasRelatedWork W2547634121 @default.

• next