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- W1933231710 abstract "Significance Fragile X syndrome (FXS) is a frequent mental disorder characterized by intellectual disability and other symptoms including autism. The disease gene-encoded protein FMRP regulates activity-dependent translation of a large number of mRNAs in neurons. We used quantitative mass spectrometry to systematically compare protein expression in neocortical synaptic fractions between Fmr1 (fragile X mental retardation 1) knockout (KO) and wild-type mice during adolescence and adulthood. We discovered an upregulation of a large number of synaptic proteins in young KO mice but not in adult ones. Many of the upregulated proteins are correlated with an increased protein synthesis in KO neurons. This study provides a greatly expanded view of protein-level changes in FXS and identifies a previously unrecognized developmental dynamics in FXS pathogenesis." @default.
- W1933231710 created "2016-06-24" @default.
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- W1933231710 date "2015-08-11" @default.
- W1933231710 modified "2023-09-30" @default.
- W1933231710 title "<i>Fmr1</i> deficiency promotes age-dependent alterations in the cortical synaptic proteome" @default.
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- W1933231710 cites W1972358546 @default.
- W1933231710 cites W1977415662 @default.
- W1933231710 cites W1979762144 @default.
- W1933231710 cites W1982281628 @default.
- W1933231710 cites W1983988073 @default.
- W1933231710 cites W1990096463 @default.
- W1933231710 cites W1990515322 @default.
- W1933231710 cites W2002760096 @default.
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- W1933231710 cites W2012322293 @default.
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- W1933231710 cites W2014981794 @default.
- W1933231710 cites W2019535057 @default.
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- W1933231710 cites W2044182049 @default.
- W1933231710 cites W2045611288 @default.
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- W1933231710 cites W2054391353 @default.
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- W1933231710 cites W2060705109 @default.
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- W1933231710 doi "https://doi.org/10.1073/pnas.1502258112" @default.
- W1933231710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4553823" @default.
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- W1933231710 hasPublicationYear "2015" @default.
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