Matches in SemOpenAlex for { <https://semopenalex.org/work/W1933235280> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1933235280 endingPage "32" @default.
- W1933235280 startingPage "528" @default.
- W1933235280 abstract "The bronchospasmolytic, antiallergic, anti-inflammatory, mucolytic and antitussive activities of 8-(2-phenylethyl)-1-oxa-diazaspiro[4,5]decan-2-one 2-tiophenecarboxylate (decasilate, CAS 76652-72-7) have been evaluated using different experimental models. 1. Decasilate showed a remarkable spasmolytic activity against histamine-induced contractions in the isolated guinea-pig tracheal preparation with an IC50 of 2.7 x 10(-6) mol/l. In addition, the oral administration of decasilate (5-30 mg.kg-1) significantly reduced the histamine aerosol-induced bronchospasm in guinea-pigs. 2. Decasilate had a preventive effect against antigen-induced contractions of ileum segments from sensitized guinea-pigs (EC50 8.0 x 10(-6) mol/l) and relaxed them when added after the antigen challenge (IC50 9.5 x 10(-7) mol/l). 3. Both carrageenin- and dextran-induced rat hind paw oedemas were significantly reduced by the oral administration of decasilate with ED50 values of 169.5 and 34.5 mg.kg-1, respectively. However, it was ineffective against the cotton pellet-induced granuloma in the rat. 4. Furthermore, decasilate had a significant mucolytic activity in rabbits and reduced the number of tussive seizures induced by an aerosol of citric acid in guinea-pigs. The pharmacological profile of decasilate suggests that it might be useful in the management of chronic bronchitis." @default.
- W1933235280 created "2016-06-24" @default.
- W1933235280 creator A5000394988 @default.
- W1933235280 creator A5017373251 @default.
- W1933235280 creator A5047722088 @default.
- W1933235280 creator A5058986521 @default.
- W1933235280 creator A5064050806 @default.
- W1933235280 date "1991-05-01" @default.
- W1933235280 modified "2023-09-23" @default.
- W1933235280 title "Evaluation of bronchospasmolytic, antiallergic, anti-inflammatory, mucolytic and antitussive activities of decasilate in experimental models." @default.
- W1933235280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1898424" @default.
- W1933235280 hasPublicationYear "1991" @default.
- W1933235280 type Work @default.
- W1933235280 sameAs 1933235280 @default.
- W1933235280 citedByCount "3" @default.
- W1933235280 crossrefType "journal-article" @default.
- W1933235280 hasAuthorship W1933235280A5000394988 @default.
- W1933235280 hasAuthorship W1933235280A5017373251 @default.
- W1933235280 hasAuthorship W1933235280A5047722088 @default.
- W1933235280 hasAuthorship W1933235280A5058986521 @default.
- W1933235280 hasAuthorship W1933235280A5064050806 @default.
- W1933235280 hasConcept C1122143 @default.
- W1933235280 hasConcept C126322002 @default.
- W1933235280 hasConcept C185592680 @default.
- W1933235280 hasConcept C202751555 @default.
- W1933235280 hasConcept C203014093 @default.
- W1933235280 hasConcept C2776042228 @default.
- W1933235280 hasConcept C2777056448 @default.
- W1933235280 hasConcept C2777226302 @default.
- W1933235280 hasConcept C2778088044 @default.
- W1933235280 hasConcept C2778815084 @default.
- W1933235280 hasConcept C2779993553 @default.
- W1933235280 hasConcept C42533223 @default.
- W1933235280 hasConcept C55493867 @default.
- W1933235280 hasConcept C71924100 @default.
- W1933235280 hasConcept C98274493 @default.
- W1933235280 hasConceptScore W1933235280C1122143 @default.
- W1933235280 hasConceptScore W1933235280C126322002 @default.
- W1933235280 hasConceptScore W1933235280C185592680 @default.
- W1933235280 hasConceptScore W1933235280C202751555 @default.
- W1933235280 hasConceptScore W1933235280C203014093 @default.
- W1933235280 hasConceptScore W1933235280C2776042228 @default.
- W1933235280 hasConceptScore W1933235280C2777056448 @default.
- W1933235280 hasConceptScore W1933235280C2777226302 @default.
- W1933235280 hasConceptScore W1933235280C2778088044 @default.
- W1933235280 hasConceptScore W1933235280C2778815084 @default.
- W1933235280 hasConceptScore W1933235280C2779993553 @default.
- W1933235280 hasConceptScore W1933235280C42533223 @default.
- W1933235280 hasConceptScore W1933235280C55493867 @default.
- W1933235280 hasConceptScore W1933235280C71924100 @default.
- W1933235280 hasConceptScore W1933235280C98274493 @default.
- W1933235280 hasIssue "5" @default.
- W1933235280 hasLocation W19332352801 @default.
- W1933235280 hasOpenAccess W1933235280 @default.
- W1933235280 hasPrimaryLocation W19332352801 @default.
- W1933235280 hasRelatedWork W1989028499 @default.
- W1933235280 hasRelatedWork W2001627900 @default.
- W1933235280 hasRelatedWork W2004085295 @default.
- W1933235280 hasRelatedWork W2006499242 @default.
- W1933235280 hasRelatedWork W2026402221 @default.
- W1933235280 hasRelatedWork W2380551151 @default.
- W1933235280 hasRelatedWork W2383745839 @default.
- W1933235280 hasRelatedWork W2400768721 @default.
- W1933235280 hasRelatedWork W2409592584 @default.
- W1933235280 hasRelatedWork W2899084033 @default.
- W1933235280 hasVolume "41" @default.
- W1933235280 isParatext "false" @default.
- W1933235280 isRetracted "false" @default.
- W1933235280 magId "1933235280" @default.
- W1933235280 workType "article" @default.