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• W1933257427 abstract "To investigate the effect of a 40 cc water-filled rectal balloon on prostate movements and on doses to the clinical target volume (CTV) and rectal wall in radiotherapy (RT) for localized prostate cancer. Ten patients were included in the study. In addition to a policy of rectum and bladder preparation (glycerol suppository 60 minutes prior to RT / empty the bladder and drink 500 millilitre water 30 minutes prior to RT), all patients were treated with the balloon. Orthogonal portal images (PI) were performed weekly during treatment to assess inter-fraction balloon displacements. Two dosimetry CT-Scans were performed prior to treatment, respectively without and with the balloon. The entire prostate was contoured as CTV. The PTV was an isotropic 1-centimetre expansion of CTV. Planning was done for the two CT separately. Initial treatment plans were copied on paired CT (without and with balloon) acquired 4 and 8 weeks later. A total of 60 CT were analysed. Dose distribution to the CTV and rectal wall during treatment course was assessed. Displacements of the prostate, rectum and balloon were measured. On PIs, mean CC and AP balloon displacements were 4.0 (range 2.9–5.1) and 3.4 (1.6–6.2) millimetres. On CT, balloon-to-prostate distance varied a mean 6.2 (1.5–18.5) and 3.4 (1.5–6.0) millimetres in the same directions. Respectively without and with the balloon, prostate displacements between consecutive CT were 4.0 (2.9–7.0) versus 3.6 (2.1–5.1) millimetres in the cranial-caudal (CC), 2.5 (1.1–3.5) versus 1.8 (1.2–2.8) in the left-right (LR), and 2.8 (1.4–4.7) versus 3.2 (1.9–4.7) millimetres in the anterior-posterior (AP) axis. All differences were non-significant. Mean and minimal doses to the CTV remained constant during treatment whether the balloon was used or not. The balloon reduced the mean rectal wall V25% by 6.5% (4.7–8.3) and V100% by 5.4% (0–12.3). There was a statistically significant relationship between an increased whole rectum volume and a decreased dose to the rectal wall. Due to large variations in balloon-to-prostate distance, the balloon should not be used to infer prostate position on PI and to reposition treatment isocentre." @default.
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• W1933257427 date "2006-11-01" @default.
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• W1933257427 title "2300" @default.
• W1933257427 doi "https://doi.org/10.1016/j.ijrobp.2006.07.708" @default.
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