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• W1933257534 startingPage "487" @default.
• W1933257534 abstract "Chimeric antigen receptor (CAR) T cells form part of a broad wave of immunotherapies that are showing promise in early phase cancer clinical trials. This clinical delivery has been based upon preclinical efficacy testing that confirmed the proof of principle of the therapy. However, CAR T-cell therapy does not exist alone as T cells are generally given in combination with patient preconditioning, most commonly in the form of chemotherapy, and may also include systemic cytokine support, both of which are associated with toxicity. Consequently, complete CAR T-cell therapy includes elements where the toxicity profile is well known, but also includes the CAR T cell itself, for which toxicity profiles are largely unknown. With recent reports of adverse events associated with CAR T-cell therapy, there is now concern that current preclinical models may not be fit for purpose with respect to CAR T-cell toxicity profiling. Here, we explore the preclinical models used to validate CAR T-cell function and examine their potential to predict CAR T-cell driven toxicities for the future." @default.
• W1933257534 created "2016-06-24" @default.
• W1933257534 creator A5009662494 @default.
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• W1933257534 date "2015-06-01" @default.
• W1933257534 modified "2023-10-14" @default.
• W1933257534 title "CAR T-cell therapy: toxicity and the relevance of preclinical models" @default.
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• W1933257534 doi "https://doi.org/10.2217/imt.14.123" @default.
• W1933257534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26065475" @default.
• W1933257534 hasPublicationYear "2015" @default.
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