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• W1933321844 endingPage "1103" @default.
• W1933321844 startingPage "1097" @default.
• W1933321844 abstract "Amide protons of peptide bonds induce an important chemical exchange saturation transfer (CEST) contrast in vivo. As a simple in vitro model for a peptide amide proton CEST effect, we suggest herein the dipeptide carnosine. We show that the metabolite carnosine creates a CEST effect and we study the properties of the exchange of the amide proton (-NH) of the carnosine peptide bond (NHCPB) in model solutions for a pH range from 6 to 8.3 and a temperature range from T = 5 °C to 43 °C by means of CEST and water exchange spectroscopy (WEX) experiments on a 3 T whole-body MR tomograph. The dependence of the NHCPB chemical exchange rate k(sw) on pH and temperature T was determined using WEX. For physiological conditions (T = 37 °C, pH = 7.10) we obtained k(sw) = (47.07 ± 7.90)/s. With similar chemical shift and exchange properties to amide protons in vivo, carnosine forms a simple model system for optimization of CEST pulse sequences in vitro. The potential for direct detection of the metabolite carnosine in vivo is discussed." @default.
• W1933321844 created "2016-06-24" @default.
• W1933321844 creator A5044807390 @default.
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• W1933321844 date "2015-07-14" @default.
• W1933321844 modified "2023-10-05" @default.
• W1933321844 title "Amide proton transfer of carnosine in aqueous solution studied <i>in vitro</i> by WEX and CEST experiments" @default.
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• W1933321844 doi "https://doi.org/10.1002/nbm.3343" @default.
• W1933321844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26179313" @default.
• W1933321844 hasPublicationYear "2015" @default.
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