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• W1933643218 abstract "A series of functionalized indolylalkylarenes 3-16(a and b) were synthesized and their affinities for the serotonin transporter were investigated in vitro. Compounds 3-12(a and b) were obtained by nucleophilic substitution of 3-(1H-indol-3-yl)propyl-4-methylbenzenesulfonates 2(a and b) with a series of azaheterocycles. Compounds 14-16(a and b) were prepared in a two-step sequence by reaction of 3-(1H-indol-3-yl)-2-methylpropanal with substituted 1,2-phenylenediamines. Compounds 3b, 4b, and 5b showed good binding affinities (K(i) = 33.0, 48.0, and 17 nM, respectively). The other synthesized compounds showed moderate or no affinity in the binding studies." @default.
• W1933643218 created "2016-06-24" @default.
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• W1933643218 date "2013-12-11" @default.
• W1933643218 modified "2023-09-23" @default.
• W1933643218 title "Synthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter" @default.
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• W1933643218 doi "https://doi.org/10.1002/ardp.201300321" @default.
• W1933643218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24339227" @default.
• W1933643218 hasPublicationYear "2013" @default.
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