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- W1933742170 abstract "Thrombospondin-1 (TSP) is a transiently expressed matricellular protein known to promote chemotaxis of leukocytes to inflammatory sites. However, TSP and its receptor CD36 are abundantly expressed in chronically inflamed tissues such as the rheumatoid synovium. Here, we show that TSP provides the costimulatory signal that is necessary for the activation of autoreactive T cells. Data presented reveal that TSP-mediated costimulation is achieved through its independent interaction with CD36 on APCs and with CD47 on T cells. We propose that a CD47-TSP-CD36 trimolecular complex is a novel costimulatory pathway that significantly decreases the threshold of T cell activation. Consistent with the paradigm that lesions in rheumatoid synovitis are sites of antigenic recognition, the characteristic focal expression of TSP on APCs such as macrophages and fibroblast-like synoviocytes suggest a central role of TSP in the expansion of tissue-infiltrating T cells." @default.
- W1933742170 created "2016-06-24" @default.
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- W1933742170 date "2000-03-15" @default.
- W1933742170 modified "2023-10-12" @default.
- W1933742170 title "Central Role of Thrombospondin-1 in the Activation and Clonal Expansion of Inflammatory T Cells" @default.
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- W1933742170 doi "https://doi.org/10.4049/jimmunol.164.6.2947" @default.
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