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• W193399648 abstract "Corticosteroids (CS) effects on insulin resistance related genes in rat skeletal muscle were studied. In our acute study, adrenalectomized (ADX) rats were given single doses of 50 mg/kg methylprednisolone (MPL) intravenously. In our chronic study, ADX rats were implanted with Alzet mini-pumps giving zero-order release rates of 0.3 mg/kg/h MPL and sacrificed at various times up to 7 days. Total RNA was extracted from gastrocnemius muscles and hybridized to Affymetrix GeneChips. Data mining and literature searches identified 6 insulin resistance related genes which exhibited complex regulatory pathways. Insulin receptor substrate-1 (IRS-1), uncoupling protein 3 (UCP3), pyruvate dehydrogenase kinase isoenzyme 4 (PDK4), fatty acid translocase (FAT) and glycerol-3-phosphate acyltransferase (GPAT) dynamic profiles were modeled with mutual effects by calculated nuclear drug-receptor complex (DR(N)) and transcription factors. The oscillatory feature of endothelin-1 (ET-1) expression was depicted by a negative feedback loop. These integrated models provide testable quantitative hypotheses for these regulatory cascades." @default.
• W193399648 created "2016-06-24" @default.
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• W193399648 date "2008-01-01" @default.
• W193399648 modified "2023-09-23" @default.
• W193399648 title "Pharmacodynamic/Pharmacogenomic Modeling of Insulin Resistance Genes in Rat Muscle after Methylprednisolone Treatment: Exploring Regulatory Signaling Cascades" @default.
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• W193399648 doi "https://doi.org/10.4137/grsb.s613" @default.
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