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- W1934357699 abstract "One of the advances in the treatment of plaque-type psoriasis is combined local therapy with calcipotriol and betamethasone. To provide both ingredients in a two-compound product, efforts have been made to unite calcipotriol and betamethasone because they are usually inactivated when present in the same formulation. This aspect was resolved when carefully designed vehicle components were invented (gel and ointment). This article reviews the efficacy, safety, and patient acceptability of calcipotriol/betamethasone dipropionate.A literature search of all articles published until February 2015 was performed, including the largest medical databases. The search strategy for evaluating the main topics of this review - efficacy, safety, and patient acceptability - was defined before checking the publications.Seventy references were found and checked for relevance. For efficacy, the proportion of patients whose psoriasis improved was always significantly higher in the two-compound group compared to the group treated with the individual substances. In the context of safety, the fixed combination was generally associated with a lower risk of adverse events. In terms of patient acceptability, the fixed combination led to a significant improvement in quality of life. The two-compound product was more convenient to handle and time saving compared to former treatments.Calcipotriol/betamethasone dipropionate in a fixed combination is an effective and well-tolerated medication in mild-to-moderate psoriasis of body and scalp and, in addition, is an evidence-based treatment modality." @default.
- W1934357699 created "2016-06-24" @default.
- W1934357699 creator A5038360062 @default.
- W1934357699 date "2015-06-01" @default.
- W1934357699 modified "2023-09-25" @default.
- W1934357699 title "Calcipotriol/betamethasone for the treatment of psoriasis: efficacy, safety, and patient acceptability" @default.
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- W1934357699 doi "https://doi.org/10.2147/ptt.s63127" @default.
- W1934357699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5683117" @default.
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- W1934357699 hasPublicationYear "2015" @default.
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