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- W1934496025 abstract "Introduction: To date, imaging of pulmonary ventilation with the hyperpolarised (HP) noble gases 3 He and 129 Xe has required ∼200 mL of 3 He or ∼500 mL of enriched Xe (86% 129 Xe) to achieve sufficient image quality for clinical interpretation. However, these gases are expensive; $850 and $170 per litre of 3 He and enriched Xe, respectively. Natural abundance (NA) Xe (26% 129 Xe) presents an attractive, economical alternative ($30 per litre) for routine imaging. Objective: To highlight the potential of NA Xe gas as a cost-effective contrast agent for imaging pulmonary ventilation. Methods: MRI was performed at 1.5T on healthy normals and smokers. 129 Xe gas was polarised to 20-30% with an in-house, regulatory-approved polariser (Norquay et al. JAP, 2013). Subjects inhaled 1L of NA Xe for a 15s breath-hold. An optimised 3D steady-state free-precession imaging sequence (Wild et al. JMR, 2006) was implemented in order to maximise the signal-to-noise ratio (SNR) and spatial resolution achieved. Results: All acquired image slices were of diagnostic quality, with SNRs of 23-30. The high SNR permitted identification of small ventilation defects in the lungs of healthy smokers (white arrows, Fig. 1). Conclusions: Optimisation of MRI pulse sequences and advances in polarisation technology can facilitate acquisition of images of pulmonary ventilation of diagnostic quality, using relatively inexpensive, readily-available NA Xe gas." @default.
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- W1934496025 date "2014-09-01" @default.
- W1934496025 modified "2023-09-27" @default.
- W1934496025 title "Feasibility of high quality lung MRI with naturally-abundant hyperpolarised 129Xe" @default.
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