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- W1934522068 abstract "This chapter presents a discussion of the various investigations of the T-locus in the hope of arriving at an integrated picture of present knowledge and of making this material accessible to further analysis with the help of present concepts and methods. A molecular study of the T-locus, with particular attention to ribosomal DNA, is suggested strongly by an apparent analogy of the t-mutants to the bobbed mutants in Drosophila. Certain attributes of the t-mutants, in particular, are reminiscent of those of bobbed mutants that have been interpreted as partial deficiencies of ribosomal DNA, and a partial deletion of the nucleolar organizer. Among the striking parallels between the two classes of mutants is, first of all, their liability as expressed in exceptionally high “mutation” rates. The mutant alleles of bobbed have been interpreted to be hypomorphs. When speculating about the possible significance of the T-locus in the mouse in processes of development and differentiation, the general problem of the relatively vast amount of DNA in the cells of higher organisms appears relevant. There has been renewed speculation about the great increase of DNA content as a possibly essential concomitant of increased complexity of organization. The chapter discusses two recent theories of gene regulation in higher cells that may be of relevance to the possible nature of this complex locus." @default.
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- W1934522068 date "1970-01-01" @default.
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- W1934522068 title "Chapter 8 The T-Locus of the Mouse: Implications for Mechanisms of Development" @default.
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- W1934522068 doi "https://doi.org/10.1016/s0070-2153(08)60058-7" @default.
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