Matches in SemOpenAlex for { <https://semopenalex.org/work/W1934539711> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1934539711 endingPage "517" @default.
- W1934539711 startingPage "512" @default.
- W1934539711 abstract "Biomarker selection through the metabolomics approach involves the acquisition of nontargeted metabolic profiles. In this study, some critical factors that may affect this process were investigated using urine test samples and a UPLC-TOF system. Repeated injections of a single sample demonstrated that the percentage of undetected and poorly repeatable measurements (intensity RSD > 15%) decreased from 22.5 to 5.8% and from 32.9 to 14.7%, respectively, as the scan time was increased up to 0.6 s (approximately 11 data points per peak). An additional critical factor was identified in the presence of broad concentration differences between the samples; the application of a dilution scheme that minimized these differences reduced the number of missing values in the final datasets by 36%. The impact of missing values was further investigated in the study of two groups of samples produced by using a spike as artificial marker. Missing values weakened the models used for the interpretation of the metabolic profiles, and greatly hindered the identification of possible markers. Finally, a simple strategy for an effective analysis of urine samples was outlined; it proved to limit the need for the post-acquisition elaboration of the data. The same strategy can easily be adapted to other matrices. Copyright © 2011 John Wiley & Sons, Ltd." @default.
- W1934539711 created "2016-06-24" @default.
- W1934539711 creator A5018240594 @default.
- W1934539711 creator A5027222246 @default.
- W1934539711 date "2011-08-16" @default.
- W1934539711 modified "2023-10-14" @default.
- W1934539711 title "Critical aspects of urine profiling for the selection of potential biomarkers using UPLC-TOF-MS" @default.
- W1934539711 cites W1968430975 @default.
- W1934539711 cites W1974777883 @default.
- W1934539711 cites W2017932539 @default.
- W1934539711 cites W2019761289 @default.
- W1934539711 cites W2022234260 @default.
- W1934539711 cites W2060778600 @default.
- W1934539711 cites W2060952451 @default.
- W1934539711 cites W2075109094 @default.
- W1934539711 cites W2087354802 @default.
- W1934539711 cites W2092623267 @default.
- W1934539711 cites W2095474836 @default.
- W1934539711 cites W2100200067 @default.
- W1934539711 cites W2101257438 @default.
- W1934539711 cites W2111369365 @default.
- W1934539711 cites W2142923621 @default.
- W1934539711 cites W2146779833 @default.
- W1934539711 cites W2151031025 @default.
- W1934539711 doi "https://doi.org/10.1002/bmc.1697" @default.
- W1934539711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22116777" @default.
- W1934539711 hasPublicationYear "2011" @default.
- W1934539711 type Work @default.
- W1934539711 sameAs 1934539711 @default.
- W1934539711 citedByCount "23" @default.
- W1934539711 countsByYear W19345397112012 @default.
- W1934539711 countsByYear W19345397112013 @default.
- W1934539711 countsByYear W19345397112014 @default.
- W1934539711 countsByYear W19345397112015 @default.
- W1934539711 countsByYear W19345397112016 @default.
- W1934539711 countsByYear W19345397112020 @default.
- W1934539711 countsByYear W19345397112021 @default.
- W1934539711 crossrefType "journal-article" @default.
- W1934539711 hasAuthorship W1934539711A5018240594 @default.
- W1934539711 hasAuthorship W1934539711A5027222246 @default.
- W1934539711 hasBestOaLocation W19345397111 @default.
- W1934539711 hasConcept C104317684 @default.
- W1934539711 hasConcept C119128265 @default.
- W1934539711 hasConcept C119857082 @default.
- W1934539711 hasConcept C121332964 @default.
- W1934539711 hasConcept C124535831 @default.
- W1934539711 hasConcept C185592680 @default.
- W1934539711 hasConcept C21565614 @default.
- W1934539711 hasConcept C2780026642 @default.
- W1934539711 hasConcept C2781197716 @default.
- W1934539711 hasConcept C41008148 @default.
- W1934539711 hasConcept C43617362 @default.
- W1934539711 hasConcept C46111723 @default.
- W1934539711 hasConcept C55493867 @default.
- W1934539711 hasConcept C9357733 @default.
- W1934539711 hasConcept C96618451 @default.
- W1934539711 hasConcept C97355855 @default.
- W1934539711 hasConceptScore W1934539711C104317684 @default.
- W1934539711 hasConceptScore W1934539711C119128265 @default.
- W1934539711 hasConceptScore W1934539711C119857082 @default.
- W1934539711 hasConceptScore W1934539711C121332964 @default.
- W1934539711 hasConceptScore W1934539711C124535831 @default.
- W1934539711 hasConceptScore W1934539711C185592680 @default.
- W1934539711 hasConceptScore W1934539711C21565614 @default.
- W1934539711 hasConceptScore W1934539711C2780026642 @default.
- W1934539711 hasConceptScore W1934539711C2781197716 @default.
- W1934539711 hasConceptScore W1934539711C41008148 @default.
- W1934539711 hasConceptScore W1934539711C43617362 @default.
- W1934539711 hasConceptScore W1934539711C46111723 @default.
- W1934539711 hasConceptScore W1934539711C55493867 @default.
- W1934539711 hasConceptScore W1934539711C9357733 @default.
- W1934539711 hasConceptScore W1934539711C96618451 @default.
- W1934539711 hasConceptScore W1934539711C97355855 @default.
- W1934539711 hasIssue "4" @default.
- W1934539711 hasLocation W19345397111 @default.
- W1934539711 hasLocation W19345397112 @default.
- W1934539711 hasOpenAccess W1934539711 @default.
- W1934539711 hasPrimaryLocation W19345397111 @default.
- W1934539711 hasRelatedWork W1969082909 @default.
- W1934539711 hasRelatedWork W2017325659 @default.
- W1934539711 hasRelatedWork W2023342487 @default.
- W1934539711 hasRelatedWork W2183621721 @default.
- W1934539711 hasRelatedWork W2228849653 @default.
- W1934539711 hasRelatedWork W2431325196 @default.
- W1934539711 hasRelatedWork W2765395567 @default.
- W1934539711 hasRelatedWork W3204734108 @default.
- W1934539711 hasRelatedWork W4200007150 @default.
- W1934539711 hasRelatedWork W4318269900 @default.
- W1934539711 hasVolume "26" @default.
- W1934539711 isParatext "false" @default.
- W1934539711 isRetracted "false" @default.
- W1934539711 magId "1934539711" @default.
- W1934539711 workType "article" @default.