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• W1934556099 abstract "Abstract This was a randomized, four‐way crossover study that evaluated the effects of placebo, single doses of ruxolitinib 25 and 200 mg, and a single dose of moxifloxacin 400 mg on heart rate‐corrected QT interval in healthy subjects. Electrocardiograms (ECGs) and pharmacokinetic samples were obtained on each dosing day; baseline ECGs were taken pre‐dose. The primary endpoint was placebo‐subtracted change from baseline heart rate‐corrected QT (Fridericia formula [ΔΔQTcF]). The ΔΔQTcF for either dose of ruxolitinib ranged from −3.09 to 3.28 milliseconds (1‐sided 95% confidence interval of 0.06–6.62 milliseconds). The ΔΔQTcF for moxifloxacin (lower confidence interval) was significantly >5 milliseconds at 1, 2, and 3 hours post‐dose. Individual QTcF >450 milliseconds and QTcF from baseline >30 milliseconds following ruxolitinib were similar to placebo. Based on the International Conference on Harmonization E14 guidance, the study results were considered negative for QTc prolongation. In conclusion, ruxolitinib did not have a clinically significant effect on QT interval." @default.
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• W1934556099 date "2014-02-06" @default.
• W1934556099 modified "2023-10-16" @default.
• W1934556099 title "Evaluation of the effect of ruxolitinib on cardiac repolarization: A thorough QT study" @default.
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• W1934556099 doi "https://doi.org/10.1002/cpdd.90" @default.
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