FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1934721550> ?p ?o ?g. }

• W1934721550 endingPage "1208" @default.
• W1934721550 startingPage "1199" @default.
• W1934721550 abstract "DNA 5' to the human epsilon-globin gene exhibits unique patterns of DNase I-hypersensitive sites (DHS) in three human erythroleukemic cell lines which represent the embryonic (K562), fetal (HEL), and adult (KMOE) stages of erythroid development. We have mapped 10 epsilon-globin DHS in K562 cells, in which the epsilon-globin gene is maximally active. Major sites are located -11.7, -10.5, -6.5, -2.2 kilobase pairs (kbp) and -200 base pairs (bp) upstream of the gene and directly over the major cap site. Minor sites are located -5.5, -4.5, and -1.48 kbp and -900 bp upstream of the cap site. In HEL cells, in which the epsilon-globin gene is expressed at extremely low levels, the -11.7-, -10.5-, -5.5-, -4.5-, and -2.2-kbp DHS are no longer detectable; the -200-bp site is approximately 300-fold less sensitive to DNase I; and the -1.48-kbp, -900-bp, and major cap site DHS are 3- to 4-fold less sensitive. Only the DHS located -6.5 kbp relative to the major cap site is detectable at all three stages of erythroid development, including KMOE cells in which epsilon-globin synthesis is undetectable. We suggest that this site may be implicated in maintaining the entire beta-globin cluster in an active chromatin conformation. The five DHS downstream of the -6.5-kbp element possess associated promoters. Thus two distinct types of DHS exist--promoter positive and promoter negative. In HEL cells, all the upstream promoters are inactivated, although the -1.48-kbp and -900- and -200-bp DHS are still present. This suggests that the maintenance of DHS and regulation of their associated promoters occur by independent mechanisms. The inactivation of the upstream promoters in HEL cells while the major cap site remains active represents a unique pattern of expression and suggests that HEL cells possess regulatory factors which specifically down regulate the epsilon-globin upstream promoters." @default.
• W1934721550 created "2016-06-24" @default.
• W1934721550 creator A5034242407 @default.
• W1934721550 creator A5069587223 @default.
• W1934721550 creator A5070271248 @default.
• W1934721550 creator A5081289293 @default.
• W1934721550 date "1990-03-01" @default.
• W1934721550 modified "2023-09-26" @default.
• W1934721550 title "Correlation between patterns of DNase I-hypersensitive sites and upstream promoter activity of the human epsilon-globin gene at different stages of erythroid development" @default.
• W1934721550 cites W1558516755 @default.
• W1934721550 cites W1888427682 @default.
• W1934721550 cites W1961455443 @default.
• W1934721550 cites W1980878206 @default.
• W1934721550 cites W1986097297 @default.
• W1934721550 cites W1995391727 @default.
• W1934721550 cites W2006918190 @default.
• W1934721550 cites W2010310450 @default.
• W1934721550 cites W2013539808 @default.
• W1934721550 cites W2017980863 @default.
• W1934721550 cites W2027486663 @default.
• W1934721550 cites W2043593473 @default.
• W1934721550 cites W2044613920 @default.
• W1934721550 cites W2050015632 @default.
• W1934721550 cites W2053166137 @default.
• W1934721550 cites W2054073262 @default.
• W1934721550 cites W2057821084 @default.
• W1934721550 cites W2060333964 @default.
• W1934721550 cites W2063450941 @default.
• W1934721550 cites W2065382698 @default.
• W1934721550 cites W2066960428 @default.
• W1934721550 cites W2068952819 @default.
• W1934721550 cites W2070537481 @default.
• W1934721550 cites W2074522847 @default.
• W1934721550 cites W2075307129 @default.
• W1934721550 cites W2079144241 @default.
• W1934721550 cites W2081875871 @default.
• W1934721550 cites W2081880782 @default.
• W1934721550 cites W2118299921 @default.
• W1934721550 cites W2125365759 @default.
• W1934721550 cites W2154372804 @default.
• W1934721550 cites W2158290831 @default.
• W1934721550 cites W2169058508 @default.
• W1934721550 cites W2344002124 @default.
• W1934721550 cites W933746562 @default.
• W1934721550 doi "https://doi.org/10.1128/mcb.10.3.1199-1208.1990" @default.
• W1934721550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/360997" @default.
• W1934721550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2304464" @default.
• W1934721550 hasPublicationYear "1990" @default.
• W1934721550 type Work @default.
• W1934721550 sameAs 1934721550 @default.
• W1934721550 citedByCount "6" @default.
• W1934721550 countsByYear W19347215502013 @default.
• W1934721550 crossrefType "journal-article" @default.
• W1934721550 hasAuthorship W1934721550A5034242407 @default.
• W1934721550 hasAuthorship W1934721550A5069587223 @default.
• W1934721550 hasAuthorship W1934721550A5070271248 @default.
• W1934721550 hasAuthorship W1934721550A5081289293 @default.
• W1934721550 hasConcept C101762097 @default.
• W1934721550 hasConcept C104317684 @default.
• W1934721550 hasConcept C125996951 @default.
• W1934721550 hasConcept C150194340 @default.
• W1934721550 hasConcept C153911025 @default.
• W1934721550 hasConcept C171122931 @default.
• W1934721550 hasConcept C182614070 @default.
• W1934721550 hasConcept C185581394 @default.
• W1934721550 hasConcept C2779377703 @default.
• W1934721550 hasConcept C3017666073 @default.
• W1934721550 hasConcept C39981086 @default.
• W1934721550 hasConcept C54355233 @default.
• W1934721550 hasConcept C552990157 @default.
• W1934721550 hasConcept C58237431 @default.
• W1934721550 hasConcept C83640560 @default.
• W1934721550 hasConcept C86803240 @default.
• W1934721550 hasConceptScore W1934721550C101762097 @default.
• W1934721550 hasConceptScore W1934721550C104317684 @default.
• W1934721550 hasConceptScore W1934721550C125996951 @default.
• W1934721550 hasConceptScore W1934721550C150194340 @default.
• W1934721550 hasConceptScore W1934721550C153911025 @default.
• W1934721550 hasConceptScore W1934721550C171122931 @default.
• W1934721550 hasConceptScore W1934721550C182614070 @default.
• W1934721550 hasConceptScore W1934721550C185581394 @default.
• W1934721550 hasConceptScore W1934721550C2779377703 @default.
• W1934721550 hasConceptScore W1934721550C3017666073 @default.
• W1934721550 hasConceptScore W1934721550C39981086 @default.
• W1934721550 hasConceptScore W1934721550C54355233 @default.
• W1934721550 hasConceptScore W1934721550C552990157 @default.
• W1934721550 hasConceptScore W1934721550C58237431 @default.
• W1934721550 hasConceptScore W1934721550C83640560 @default.
• W1934721550 hasConceptScore W1934721550C86803240 @default.
• W1934721550 hasIssue "3" @default.
• W1934721550 hasLocation W19347215501 @default.
• W1934721550 hasOpenAccess W1934721550 @default.
• W1934721550 hasPrimaryLocation W19347215501 @default.
• W1934721550 hasRelatedWork W1934721550 @default.
• W1934721550 hasRelatedWork W1982871342 @default.
• W1934721550 hasRelatedWork W1997076676 @default.
• W1934721550 hasRelatedWork W2013457082 @default.
• W1934721550 hasRelatedWork W2048954418 @default.

• next