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- W1934974799 abstract "Trospectomycin, unlike aminoglycosidic aminocyclitols, is accumulated by a nonsaturable, energy-independent, diffusional process in Salmonella typhimurium, Escherichia coli and Haemophilus influenzae. A deep rough mutant of S typhimurium was more susceptible and accumulated the drug faster, and F porin deficient mutants of E coli were more resistant than parental strains. Trospectomycin likely uses both porin and nonporin pathways to cross the outer membrane. An E coli strain effectively accumulated the drug anaerobically, explaining its anaerobic activity. An H influenzae strain accumulated trospectomycin at concentrations below those for which detectable uptake could be observed with E coli or S typhimurium strains, consistent with greater activity in Haemophilus species." @default.
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- W1934974799 date "1990-01-01" @default.
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- W1934974799 title "Accumulation of Trospectomycin by Strains ofSalmonella typhimurium, escherichia coliandHaemophilus influenzae" @default.
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- W1934974799 doi "https://doi.org/10.1155/1990/258273" @default.
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