FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1935224629> ?p ?o ?g. }

• W1935224629 endingPage "1724" @default.
• W1935224629 startingPage "1717" @default.
• W1935224629 abstract "Objectives/Hypothesis Vocal cord scar formation and laryngotracheal stenosis (LTS) are challenging problems for otolaryngologists. Sendai virus (SeV) vectors have been shown to transduce airway epithelium efficiently, and are thus ideal for modulating airway wound‐healing therapy. To assess the potential utility of SeV gene therapy for laryngotracheal diseases, we established a novel LTS model and examined the transduction efficiency of SeV vectors in normal and LTS model tissue. Study Design Basic science. Methods Fusion (F) gene‐deleted, nontransmissible SeV vectors were used. First, the route dependency and transduction efficiency of SeV vectors for normal mucosa in the larynx were examined. Next, the novel LTS rat model was established and evaluated. Finally, the transduction efficiency of SeV vectors in injured mucosa of the LTS model was evaluated. Results Simple spray delivery of the SeV vector resulted in significant and persistent expression of the reporter gene in normal laryngotracheal epithelium. Transgenic SeV‐mediated expression was maximal at 3 days, decreased over time, but remained detectable for 14 days after administration. No serious side effects were observed in the larynx or trachea. The model achieved an average of 60% tracheal stenosis in the cross‐sectional area. Efficient SeV‐mediated transgene expression was observed in the injured mucosa at the levels of the trachea, cricoid cartilage, and vocal cord. Conclusion A novel animal model for LTS was established. We successfully demonstrated SeV‐mediated transgene expression in normal tissue and in the injured mucosa of the LTS model. SeV might be a promising strategy for gene therapy in laryngotracheal diseases. Level of Evidence N/A." @default.
• W1935224629 created "2016-06-24" @default.
• W1935224629 creator A5018941611 @default.
• W1935224629 creator A5019985125 @default.
• W1935224629 creator A5021031031 @default.
• W1935224629 creator A5038759160 @default.
• W1935224629 creator A5049145632 @default.
• W1935224629 creator A5058867062 @default.
• W1935224629 creator A5068216885 @default.
• W1935224629 creator A5073445237 @default.
• W1935224629 creator A5080523755 @default.
• W1935224629 date "2013-05-10" @default.
• W1935224629 modified "2023-10-14" @default.
• W1935224629 title "Sendai virus transgene in a novel gene therapy for laryngotracheal disease" @default.
• W1935224629 cites W1553961669 @default.
• W1935224629 cites W1967344018 @default.
• W1935224629 cites W1968625045 @default.
• W1935224629 cites W1994325819 @default.
• W1935224629 cites W1998588332 @default.
• W1935224629 cites W2001469906 @default.
• W1935224629 cites W2001607183 @default.
• W1935224629 cites W2001819832 @default.
• W1935224629 cites W2005411001 @default.
• W1935224629 cites W2034657507 @default.
• W1935224629 cites W2061991700 @default.
• W1935224629 cites W2070733098 @default.
• W1935224629 cites W2083068373 @default.
• W1935224629 cites W2097437727 @default.
• W1935224629 cites W2110208429 @default.
• W1935224629 cites W2140562414 @default.
• W1935224629 cites W2324043536 @default.
• W1935224629 cites W2325918358 @default.
• W1935224629 doi "https://doi.org/10.1002/lary.23917" @default.
• W1935224629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23666749" @default.
• W1935224629 hasPublicationYear "2013" @default.
• W1935224629 type Work @default.
• W1935224629 sameAs 1935224629 @default.
• W1935224629 citedByCount "11" @default.
• W1935224629 countsByYear W19352246292015 @default.
• W1935224629 countsByYear W19352246292018 @default.
• W1935224629 countsByYear W19352246292020 @default.
• W1935224629 countsByYear W19352246292021 @default.
• W1935224629 countsByYear W19352246292023 @default.
• W1935224629 crossrefType "journal-article" @default.
• W1935224629 hasAuthorship W1935224629A5018941611 @default.
• W1935224629 hasAuthorship W1935224629A5019985125 @default.
• W1935224629 hasAuthorship W1935224629A5021031031 @default.
• W1935224629 hasAuthorship W1935224629A5038759160 @default.
• W1935224629 hasAuthorship W1935224629A5049145632 @default.
• W1935224629 hasAuthorship W1935224629A5058867062 @default.
• W1935224629 hasAuthorship W1935224629A5068216885 @default.
• W1935224629 hasAuthorship W1935224629A5073445237 @default.
• W1935224629 hasAuthorship W1935224629A5080523755 @default.
• W1935224629 hasConcept C102230213 @default.
• W1935224629 hasConcept C104317684 @default.
• W1935224629 hasConcept C105702510 @default.
• W1935224629 hasConcept C105922876 @default.
• W1935224629 hasConcept C111599444 @default.
• W1935224629 hasConcept C135983454 @default.
• W1935224629 hasConcept C141071460 @default.
• W1935224629 hasConcept C142724271 @default.
• W1935224629 hasConcept C15152581 @default.
• W1935224629 hasConcept C203014093 @default.
• W1935224629 hasConcept C2522874641 @default.
• W1935224629 hasConcept C2778560121 @default.
• W1935224629 hasConcept C2780127873 @default.
• W1935224629 hasConcept C2780474809 @default.
• W1935224629 hasConcept C2908550248 @default.
• W1935224629 hasConcept C529295009 @default.
• W1935224629 hasConcept C55493867 @default.
• W1935224629 hasConcept C71924100 @default.
• W1935224629 hasConcept C86803240 @default.
• W1935224629 hasConcept C87568996 @default.
• W1935224629 hasConceptScore W1935224629C102230213 @default.
• W1935224629 hasConceptScore W1935224629C104317684 @default.
• W1935224629 hasConceptScore W1935224629C105702510 @default.
• W1935224629 hasConceptScore W1935224629C105922876 @default.
• W1935224629 hasConceptScore W1935224629C111599444 @default.
• W1935224629 hasConceptScore W1935224629C135983454 @default.
• W1935224629 hasConceptScore W1935224629C141071460 @default.
• W1935224629 hasConceptScore W1935224629C142724271 @default.
• W1935224629 hasConceptScore W1935224629C15152581 @default.
• W1935224629 hasConceptScore W1935224629C203014093 @default.
• W1935224629 hasConceptScore W1935224629C2522874641 @default.
• W1935224629 hasConceptScore W1935224629C2778560121 @default.
• W1935224629 hasConceptScore W1935224629C2780127873 @default.
• W1935224629 hasConceptScore W1935224629C2780474809 @default.
• W1935224629 hasConceptScore W1935224629C2908550248 @default.
• W1935224629 hasConceptScore W1935224629C529295009 @default.
• W1935224629 hasConceptScore W1935224629C55493867 @default.
• W1935224629 hasConceptScore W1935224629C71924100 @default.
• W1935224629 hasConceptScore W1935224629C86803240 @default.
• W1935224629 hasConceptScore W1935224629C87568996 @default.
• W1935224629 hasIssue "7" @default.
• W1935224629 hasLocation W19352246291 @default.
• W1935224629 hasLocation W19352246292 @default.
• W1935224629 hasOpenAccess W1935224629 @default.
• W1935224629 hasPrimaryLocation W19352246291 @default.

• next