Matches in SemOpenAlex for { <https://semopenalex.org/work/W1935281646> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1935281646 endingPage "906" @default.
- W1935281646 startingPage "899" @default.
- W1935281646 abstract "In lung cancer patients tumor markers are used for disease monitoring. The goal of this study was to improve diagnostic efficiency in the detection of tumor progression in lung cancer patients by using fuzzy logic modeling in combination with a tumor marker panel (Tumor M2-PK, CYFRA 21-1, CEA, NSE and SCC). Thirty-three small cell lung cancers (SCLC) and 69 consecutive inoperable patients (40 squamous and 29 adenocarcinomas) were included in a prospective study. The changes of blood levels of tumor markers as well as their analysis by fuzzy logic modelling were compared to the clinical evaluation of response vs. non-response to therapy. Clinical monitoring was evaluated according to the standard criteria of the WHO. Tumor M2-PK was measured in plasma with an ELISA (ScheBo Biotech, Germany) and all other markers in sera (Roche, Germany). At a 90% specificity, the respective best single marker found the following fraction of all patients who had tumor progression clinically detected: in SCLC with NSE 52%, in adenocarcinoma with CYFRA 21-1 89% and in squamous carcinoma with SCC 65%. A fuzzy logic rule-based system employing a tumor marker panel increased the sensitivity in small cell carcinomas to 73% with the marker combination NSE/CEA and to 63% with the marker combination NSE/Tumor M2-PK, respectively. In squamous carcinomas an improvement of sensitivity is also observed using the marker combination of SCC/Tumor M2-PK (Sensitivity: 81%) or SCC/CEA (Sensitivity: 71%). By using the fuzzy logic method and the marker combination CYFRA 21-1/CEA as well as CYFRA 21-1/Tumor M2-PK, the detection of lung cancer progression was possible in all adenocarcinomas. With the fuzzy logic method and a tumor marker panel (including the new marker Tumor M2-PK), a useful diagnostic tool for the detection of progression in lung cancer patients is available." @default.
- W1935281646 created "2016-06-24" @default.
- W1935281646 creator A5000322005 @default.
- W1935281646 creator A5017500848 @default.
- W1935281646 creator A5020570296 @default.
- W1935281646 creator A5053868569 @default.
- W1935281646 creator A5055800261 @default.
- W1935281646 creator A5072692914 @default.
- W1935281646 creator A5074837397 @default.
- W1935281646 creator A5088721842 @default.
- W1935281646 date "2003-06-25" @default.
- W1935281646 modified "2023-09-23" @default.
- W1935281646 title "Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients." @default.
- W1935281646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12820320" @default.
- W1935281646 hasPublicationYear "2003" @default.
- W1935281646 type Work @default.
- W1935281646 sameAs 1935281646 @default.
- W1935281646 citedByCount "13" @default.
- W1935281646 countsByYear W19352816462012 @default.
- W1935281646 countsByYear W19352816462014 @default.
- W1935281646 countsByYear W19352816462016 @default.
- W1935281646 crossrefType "journal-article" @default.
- W1935281646 hasAuthorship W1935281646A5000322005 @default.
- W1935281646 hasAuthorship W1935281646A5017500848 @default.
- W1935281646 hasAuthorship W1935281646A5020570296 @default.
- W1935281646 hasAuthorship W1935281646A5053868569 @default.
- W1935281646 hasAuthorship W1935281646A5055800261 @default.
- W1935281646 hasAuthorship W1935281646A5072692914 @default.
- W1935281646 hasAuthorship W1935281646A5074837397 @default.
- W1935281646 hasAuthorship W1935281646A5088721842 @default.
- W1935281646 hasConcept C121608353 @default.
- W1935281646 hasConcept C126322002 @default.
- W1935281646 hasConcept C142724271 @default.
- W1935281646 hasConcept C143998085 @default.
- W1935281646 hasConcept C192638826 @default.
- W1935281646 hasConcept C2776256026 @default.
- W1935281646 hasConcept C2779256057 @default.
- W1935281646 hasConcept C2780521871 @default.
- W1935281646 hasConcept C2781182431 @default.
- W1935281646 hasConcept C2781447364 @default.
- W1935281646 hasConcept C71924100 @default.
- W1935281646 hasConceptScore W1935281646C121608353 @default.
- W1935281646 hasConceptScore W1935281646C126322002 @default.
- W1935281646 hasConceptScore W1935281646C142724271 @default.
- W1935281646 hasConceptScore W1935281646C143998085 @default.
- W1935281646 hasConceptScore W1935281646C192638826 @default.
- W1935281646 hasConceptScore W1935281646C2776256026 @default.
- W1935281646 hasConceptScore W1935281646C2779256057 @default.
- W1935281646 hasConceptScore W1935281646C2780521871 @default.
- W1935281646 hasConceptScore W1935281646C2781182431 @default.
- W1935281646 hasConceptScore W1935281646C2781447364 @default.
- W1935281646 hasConceptScore W1935281646C71924100 @default.
- W1935281646 hasIssue "2A" @default.
- W1935281646 hasLocation W19352816461 @default.
- W1935281646 hasOpenAccess W1935281646 @default.
- W1935281646 hasPrimaryLocation W19352816461 @default.
- W1935281646 hasRelatedWork W1935281646 @default.
- W1935281646 hasRelatedWork W1978674924 @default.
- W1935281646 hasRelatedWork W2028974213 @default.
- W1935281646 hasRelatedWork W2043892999 @default.
- W1935281646 hasRelatedWork W2258493256 @default.
- W1935281646 hasRelatedWork W2352564820 @default.
- W1935281646 hasRelatedWork W2352723021 @default.
- W1935281646 hasRelatedWork W2357654779 @default.
- W1935281646 hasRelatedWork W2375090955 @default.
- W1935281646 hasRelatedWork W2403361534 @default.
- W1935281646 hasVolume "23" @default.
- W1935281646 isParatext "false" @default.
- W1935281646 isRetracted "false" @default.
- W1935281646 magId "1935281646" @default.
- W1935281646 workType "article" @default.