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• W1935364242 abstract "Type 1 fimbriae promote enterobacterial adherence to a variety of mammalian cells and are thought to play an important role in the establishment of various extraintestinal infections. Whether or not this adhesin has a role in the pathogenesis of peritoneal Escherichia coli infections, such as those initiated by bowel leakage during intraabdominal surgery, is unclear. By using two genetically engineered E. coli strains, each bearing an antibiotic resistance element inserted at a different site within the type 1 fimbria operon, we examined the role of type 1 fimbriation in intraperitoneal infection in rats. A permanently nonfimbriated insertion mutant was compared with an analogously constructed normally fimbriated one. After intraperitoneal inoculation of adult rats, the permanently nonfimbriated mutant produced mortality more rapidly and resulted in a greater number of culturable organisms from both the peritoneum and the blood. Moreover, the differences between these two insertion mutants were dramatically enhanced by preinoculation growth conditions favoring fimbrial expression. After growth under these conditions, 10(3) CFU of the fimbriation-proficient strain inoculated intraperitoneally caused no mortality; in sharp contrast, the permanently nonfimbriated insertion mutant resulted in death in 60% of the animals inoculated. Notwithstanding evidence that type 1 fimbriae mediate enterobacterial adherence to mammalian oropharyngeal and bladder mucosae, the results presented here demonstrate that type 1 fimbrial expression can lead to diminution of the number of E. coli organisms within the peritoneum." @default.
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• W1935364242 date "1993-05-01" @default.
• W1935364242 modified "2023-09-23" @default.
• W1935364242 title "Enhanced virulence of Escherichia coli bearing a site-targeted mutation in the major structural subunit of type 1 fimbriae" @default.
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• W1935364242 doi "https://doi.org/10.1128/iai.61.5.1667-1673.1993" @default.
• W1935364242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/280749" @default.
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