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• W1935396239 abstract "Proteins and enzymes with nonhaem iron centres display many functions: metal centres with primarily sulfur ligation are involved in electron transfer, electrophilic activation of hydroxyl groups, fixation of N2 and regulation of gene expression; mononuclear and diiron centres with oxygen and nitrogen ligation have roles in various reactions with O2 and in hydrolysis. The principles of their mechanisms of action have emerged from considerable experimentation. Ongoing research is refining understanding of their mechanisms of action and attempting to test and extend their already substantial catalytic capabilities.Key Concepts Nonhaem iron-containing enzymes carry out a myriad of catalytic reactions.Iron–sulfur centres participate in electron transfer, electrophilic catalysis, nitrogenase and hydrogenase reactions.Mononuclear and diiron monooxygenases, dioxygenases and oxidases provide nonhaem counterparts to catalysis carried out by haem-containing enzymes.Rearrangements of protein ligands in nonhaem iron active sites provide a unique aspect to control catalysis.Nonhaem oxidative enzymes access high-valent states of iron during catalysis.The electrophilic nature of nonhaem iron also supports effective hydrolytic catalysis in reactions where O2 activation is not required.Keywords:iron;enzyme mechanism;enzyme structure;enzyme specificity;metalloproteins;iron–sulfur clusters;nitrogenase;hydrogenase;S-adenosylmethionine;radical SAM;hydrogenase;monooxygenase;dioxygenase;lipoxygenase;transferrin;diiron;haemerythrin;ferritin;ribonucleotide reductase;desaturase" @default.
• W1935396239 created "2016-06-24" @default.
• W1935396239 creator A5027461170 @default.
• W1935396239 date "2015-10-15" @default.
• W1935396239 modified "2023-09-24" @default.
• W1935396239 title "Iron Cofactors: Nonhaem" @default.
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• W1935396239 doi "https://doi.org/10.1002/9780470015902.a0000668.pub3" @default.
• W1935396239 hasPublicationYear "2015" @default.
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