FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1935417005> ?p ?o ?g. }

• W1935417005 endingPage "3295" @default.
• W1935417005 startingPage "3284" @default.
• W1935417005 abstract "Chemoreceptors are at the beginning of chemosensory pathways that mediate chemotaxis. Pseudomonas putida KT2440 is predicted to have 27 chemoreceptors, most of which uncharacterized. We have previously identified McpS as chemoreceptor for Krebs cycle intermediates. Citrate is primarily present in the environment as metal complex, which, however, is not recognized by McpS. We show here that the McpS paralogue McpQ recognizes specifically citrate and citrate/metal2+ complexes. The McpQ ligand binding domain (McpQ-LBD) binds citrate/metal2+ complexes with higher affinity than citrate. McpQ-LBD is present in a monomer-dimer equilibrium and citrate and particularly citrate/Mg2+ binding stabilize the dimer. The bacterium showed much stronger responses to citrate/Mg2+ than to citrate and mcpQ inactivation caused a dramatic reduction in chemotaxis. Responses to Krebs cycle intermediates are thus mediated by the broad range McpS and McpQ that responds specifically to an intermediate not recognized by McpS. Interesting parallels exist to the paralogous amino acid chemoreceptors of Pseudomonas aeruginosa and Bacillus subtilis. Whereas one paralogue recognizes most amino acids, the remaining paralogue binds specifically one of the few acids not recognized by the broad range receptors. Therefore, chemotaxis to compound families by the concerted action of broad and narrow range receptors may represent a general mechanism." @default.
• W1935417005 created "2016-06-24" @default.
• W1935417005 creator A5003034143 @default.
• W1935417005 creator A5006711743 @default.
• W1935417005 creator A5026152833 @default.
• W1935417005 creator A5035438356 @default.
• W1935417005 creator A5042805502 @default.
• W1935417005 creator A5061404485 @default.
• W1935417005 date "2015-10-14" @default.
• W1935417005 modified "2023-10-17" @default.
• W1935417005 title "McpQ is a specific citrate chemoreceptor that responds preferentially to citrate/metal ion complexes" @default.
• W1935417005 cites W128133615 @default.
• W1935417005 cites W1507735095 @default.
• W1935417005 cites W1546130662 @default.
• W1935417005 cites W1562607711 @default.
• W1935417005 cites W1564881569 @default.
• W1935417005 cites W1573831007 @default.
• W1935417005 cites W1579422048 @default.
• W1935417005 cites W1631101819 @default.
• W1935417005 cites W1749993378 @default.
• W1935417005 cites W1824614244 @default.
• W1935417005 cites W1841773228 @default.
• W1935417005 cites W1885931955 @default.
• W1935417005 cites W1899503782 @default.
• W1935417005 cites W1920238277 @default.
• W1935417005 cites W1965100720 @default.
• W1935417005 cites W1972918463 @default.
• W1935417005 cites W1974636817 @default.
• W1935417005 cites W1975317507 @default.
• W1935417005 cites W1975993749 @default.
• W1935417005 cites W1977125035 @default.
• W1935417005 cites W1980828843 @default.
• W1935417005 cites W1986874145 @default.
• W1935417005 cites W1989639494 @default.
• W1935417005 cites W1991174368 @default.
• W1935417005 cites W2012031105 @default.
• W1935417005 cites W2014202830 @default.
• W1935417005 cites W2029024880 @default.
• W1935417005 cites W2043488671 @default.
• W1935417005 cites W2050499271 @default.
• W1935417005 cites W2052509575 @default.
• W1935417005 cites W2058263784 @default.
• W1935417005 cites W2060259273 @default.
• W1935417005 cites W2063404970 @default.
• W1935417005 cites W2069226360 @default.
• W1935417005 cites W2070720273 @default.
• W1935417005 cites W2072788975 @default.
• W1935417005 cites W2078358686 @default.
• W1935417005 cites W2079673773 @default.
• W1935417005 cites W2080208401 @default.
• W1935417005 cites W2082727114 @default.
• W1935417005 cites W2084617901 @default.
• W1935417005 cites W2088747344 @default.
• W1935417005 cites W2092567877 @default.
• W1935417005 cites W2103775656 @default.
• W1935417005 cites W2106976657 @default.
• W1935417005 cites W2110616103 @default.
• W1935417005 cites W2114946780 @default.
• W1935417005 cites W2115543757 @default.
• W1935417005 cites W2115840790 @default.
• W1935417005 cites W2120892978 @default.
• W1935417005 cites W2126849248 @default.
• W1935417005 cites W2133900508 @default.
• W1935417005 cites W2134864306 @default.
• W1935417005 cites W2138548246 @default.
• W1935417005 cites W2143920705 @default.
• W1935417005 cites W2150725310 @default.
• W1935417005 cites W2157098087 @default.
• W1935417005 cites W2158250020 @default.
• W1935417005 cites W2161178127 @default.
• W1935417005 cites W2166281119 @default.
• W1935417005 cites W2166362719 @default.
• W1935417005 cites W2315576830 @default.
• W1935417005 cites W317674588 @default.
• W1935417005 doi "https://doi.org/10.1111/1462-2920.13030" @default.
• W1935417005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26463109" @default.
• W1935417005 hasPublicationYear "2015" @default.
• W1935417005 type Work @default.
• W1935417005 sameAs 1935417005 @default.
• W1935417005 citedByCount "37" @default.
• W1935417005 countsByYear W19354170052015 @default.
• W1935417005 countsByYear W19354170052016 @default.
• W1935417005 countsByYear W19354170052017 @default.
• W1935417005 countsByYear W19354170052018 @default.
• W1935417005 countsByYear W19354170052019 @default.
• W1935417005 countsByYear W19354170052020 @default.
• W1935417005 countsByYear W19354170052021 @default.
• W1935417005 countsByYear W19354170052022 @default.
• W1935417005 countsByYear W19354170052023 @default.
• W1935417005 crossrefType "journal-article" @default.
• W1935417005 hasAuthorship W1935417005A5003034143 @default.
• W1935417005 hasAuthorship W1935417005A5006711743 @default.
• W1935417005 hasAuthorship W1935417005A5026152833 @default.
• W1935417005 hasAuthorship W1935417005A5035438356 @default.
• W1935417005 hasAuthorship W1935417005A5042805502 @default.
• W1935417005 hasAuthorship W1935417005A5061404485 @default.
• W1935417005 hasConcept C103247709 @default.
• W1935417005 hasConcept C116569031 @default.

• next