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- W1935532468 abstract "<h3>Introduction</h3> Only 30–40% of depressed patients treated with medication achieve full remission. Studies that change medication or augment it by psychotherapy achieve only limited benefits, in part because current treatments are not designed for chronic and complex patients. Previous trials have excluded high-risk patients and those with comorbid personality disorder. Radically Open Dialectical Behaviour Therapy (RO-DBT) is a novel, transdiagnostic treatment for disorders of emotional over-control. The REFRAMED trial aims to evaluate the effectiveness and cost-effectiveness of RO-DBT for patients with treatment-resistant depression. <h3>Methods and analysis</h3> REFRAMED is a multicentre randomised controlled trial, comparing 7 months of individual and group RO-DBT treatment with treatment as usual (TAU). Our primary outcome measure is depressive symptoms 12 months after randomisation. We shall estimate the cost-effectiveness of RO-DBT by cost per quality-adjusted life year. Causal analyses will explore the mechanisms by which RO-DBT is effective. <h3>Ethics and dissemination</h3> The National Research Ethics Service (NRES) Committee South Central – Southampton A first granted ethical approval on 20 June 2011, reference number 11/SC/0146. <h3>Trial registration number</h3> ISRCTN85784627." @default.
- W1935532468 created "2016-06-24" @default.
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- W1935532468 date "2015-07-01" @default.
- W1935532468 modified "2023-09-27" @default.
- W1935532468 title "Refractory depression: mechanisms and evaluation of radically open dialectical behaviour therapy (RO-DBT) [REFRAMED]: protocol for randomised trial" @default.
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- W1935532468 doi "https://doi.org/10.1136/bmjopen-2015-008857" @default.
- W1935532468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4513446" @default.
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- W1935532468 hasPublicationYear "2015" @default.
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