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- W1935603722 abstract "Leucocyte telomere length (LTL) is associated with age-related health outcomes, but only few longitudinal studies have assessed changes in LTL in an ageing population.A total of 1,082 subjects from the Helsinki Birth Cohort Study (born 1934-1944), undergoing two clinical visits ∼10 years apart, were studied. Relative LTL was measured twice by quantitative real-time PCR. Simple and multiple regressions were used to study associations between cardiometabolic risk factors and LTL.Telomere shortening was observed in 93.7%, and telomere elongation in 6.3% of the study participants. Telomere shortening was more rapid among males (-39.5% ± 1.1% versus -35.5% ± 1.0%, P < 0.01). In men a decrease in weight, waist circumference, BMI, and body fat percentage were all associated with telomere shortening during the follow-up (P < 0.05) independently of age and use of medication. Furthermore, higher body fat percentage and higher HDL-cholesterol level were associated with a slower rate of shortening in LTL (P < 0.05). Lower blood pressure levels were also associated with slower rate of telomere shortening in men (P < 0.05). No similar associations were observed among women.A decrease in adiposity was associated with telomere shortening, and higher body fat percentage and HDL-cholesterol were associated with a slower rate of shortening in telomere length in men." @default.
- W1935603722 created "2016-06-24" @default.
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- W1935603722 date "2015-08-18" @default.
- W1935603722 modified "2023-09-27" @default.
- W1935603722 title "Rate of telomere shortening and metabolic and cardiovascular risk factors: A longitudinal study in the 1934–44 Helsinki Birth Cohort Study" @default.
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- W1935603722 doi "https://doi.org/10.3109/07853890.2015.1074718" @default.
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