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• W193564708 endingPage "H1962" @default.
• W193564708 startingPage "H1954" @default.
• W193564708 abstract "Genetically modified mice have created the need for accurate noninvasive left ventricular mass (LVM) measurements. Recent technical advances provide two-dimensional images adequate for LVM calculation using the area-length method, which in humans is more accurate than M-mode methods. We compared the standard M-mode and area-length methods in mice over a wide range of LV sizes and weights (62-210 mg). Ninety-one CD-1 mice (38 normal, 44 aortic banded, and 9 inherited dilated cardiomyopathy) were imaged transthoracically (15 MHz linear transducer, 120 Hz). Compared with necropsy weights, area-length measurements showed higher correlation than the M-mode method (r = 0.92 vs. 0.81), increased accuracy (bias +/- SD: 1.4 +/- 27.1% vs. 36.7 +/- 51.6%), and improved reproducibility. There was no significant difference between end-systolic and end-diastolic estimates. The truncated ellipsoid estimation produced results similar in accuracy to the area-length method. Whereas current echocardiographic technology can accurately and reproducibly estimate LVM with the two-dimensional, area-length formula in a variety of mouse models, additional technological improvements, rather than refinement of geometric models, will likely improve the accuracy of this methodology." @default.
• W193564708 created "2016-06-24" @default.
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• W193564708 date "2001-05-01" @default.
• W193564708 modified "2023-10-02" @default.
• W193564708 title "Accuracy of echocardiographic estimates of left ventricular mass in mice" @default.
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• W193564708 doi "https://doi.org/10.1152/ajpheart.2001.280.5.h1954" @default.
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