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• W1935672226 endingPage "741" @default.
• W1935672226 startingPage "733" @default.
• W1935672226 abstract "Summary. Gas6 (encoded by growth arrest-specific gene 6) is a vitamin-K dependent protein highly homologous to coagulation protein S that is secreted from platelet α-granules and has recently been demonstrated to participate in platelet thrombus formation. The current study evaluated the contribution of each of the three known Gas6 receptors (Axl, Sky and Mer) in human and mouse platelet function. Flow cytometry analyses confirmed that all three receptors are present on both human and mouse platelets. Pre-incubation of human platelets with either an anti-Gas6 antibody or blocking antibodies to Sky or Mer inhibited platelet aggregation and degranulation responses to both ADP and the PAR-1 activating peptide, SFLLRN, by more than 80%. In contrast, a stimulatory anti-Axl antibody increased activation responses to these agonists, suggesting a potentiating role for Gas6 in platelet activation. Moreover, in a mouse model of thrombosis, administration of Gas6 or Sky blocking antibodies resulted in a decrease in thrombus weight similar to clopidogrel but, unlike clopidogrel, produced no increase in template bleeding. Thus, Gas6 enhances platelet degranulation and aggregation responses through its known receptors, promoting platelet activation and mediating thrombus formation such that its inhibition prevents thrombosis without increasing bleeding." @default.
• W1935672226 created "2016-06-24" @default.
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• W1935672226 date "2005-04-01" @default.
• W1935672226 modified "2023-10-03" @default.
• W1935672226 title "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses" @default.
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• W1935672226 doi "https://doi.org/10.1111/j.1538-7836.2005.01186.x" @default.
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