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• W1935855412 abstract "Fibroblast low density lipoprotein (LDL) plasma membrane receptor activity, measured as 125I-LDL association (plasma membrane binding plus intracellular accumulation) and degradation was determined in cell strains from 14 monozygotic (MZ) and 21 like-sexed dizygotic (DZ) normolipidemic twin pairs. The twins were between 57 and 62 years old and had lived apart for an average of 38 years (range 0–60). The intrapair differences were significantly smaller in MZ than in DZ twin pairs in fibroblast 125I-LDL association as well as degradation assays (P < 0.05). These findings suggest a genetic influence on normal variation in LDL receptor activity in vitro. In two MZ pairs discordant for psoriasis, the psoriatic twin had markedly lower LDL receptor activity than the cotwin." @default.
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• W1935855412 date "2008-04-23" @default.
• W1935855412 modified "2023-10-18" @default.
• W1935855412 title "Genetics of the low density lipoprotein receptor:" @default.
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• W1935855412 doi "https://doi.org/10.1111/j.1399-0004.1981.tb01815.x" @default.
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